A New Synthetic Route to Optically Active α, β- and β', γ'-Unsaturated Alcohols, and Its Application to the Synthesis of a Fungitoxic C-18 Hydroxy Unsaturated Fatty Acid

doi:10.1248/cpb.37.2610

2 0 0 0 OA A New Synthetic Route to Optically Active α, β- and β', γ'-Unsaturated Alcohols, and Its Application to the Synthesis of a Fungitoxic C-18 Hydroxy Unsaturated Fatty Acid

著者: 樫原宏末宗洋藤本勝彦酒井浄
出版者: The Pharmaceutical Society of Japan
雑誌: Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日: vol.37, no.10, pp.2610-2614, 1989-10-25 (Released:2008-03-31)
参考文献数: 17
被引用文献数: 7 9

A new synthetic route to optically active α, β-, β', γ'-unsaturated alcohols was established. The chiral enones (6 and 8), prepared from dimethyl malate via chiral phosphonates (4 and 5), were diastereoselectively reduced with Zn(BH4)2 to afford the 1, 3-syn derivatives (9 and 11). As an application of this 1, 3-asymmetric induction, the fungitoxic C-18 hydroxy unsaturated fatty acid isolated from stromata of Epichloe typhina was synthesized.

2022-02-04 22:11:19
2 + 3 Twitter

言及状況

外部データベース (DOI)

Twitter (2 users, 3 posts, 3 favorites)

A New Synthetic Route to Optically Active α, β- and β', γ'-Unsaturated Alcohols, and Its Application to the Synthesis of a Fungitoxic C-18 Hydroxy Unsaturated Fatty Acid 樫原宏 Chemical and Pharmaceutical Bulletin 1989 年 https://t.co/SXedCzwhgk

3 @hitomihoumu @hitomihoumuhara @jama_muyo

2 0 0 0 OA A New Synthetic Route to Optically Active α, β- and β', γ'-Unsaturated Alcohols, and Its Application to the Synthesis of a Fungitoxic C-18 Hydroxy Unsaturated Fatty Acid

言及状況

外部データベース (DOI)

Twitter (2 users, 3 posts, 3 favorites)

収集済み URL リスト