2 0 0 0 OA Facile Synthesis of Furan Derivatives
- 著者
- 樫原 宏 末宗 洋 常広 菜穂美 酒井 浄
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.38, no.9, pp.2581-2582, 1990-09-25 (Released:2008-03-31)
- 参考文献数
- 17
- 被引用文献数
- 2 3
The enones (II), which were obtained from dimethyl 4, 5-isopropylidenedioxy-2-oxopentylphosphonate (Ia) and various aldehydes, were easily converted to 2-alkenylfurans (III) by treatment with p-TsOH in MeOH. In a similar manner, the furfuryl phosphonate (IVa) and the 3-methylfurfuryl phosphonate (IVb) were obtained from Ia and its 3-methylated analogue (Ib), respectively.
- 著者
- 樫原 宏 末宗 洋 藤本 勝彦 酒井 浄
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.37, no.10, pp.2610-2614, 1989-10-25 (Released:2008-03-31)
- 参考文献数
- 17
- 被引用文献数
- 7 9
A new synthetic route to optically active α, β-, β', γ'-unsaturated alcohols was established. The chiral enones (6 and 8), prepared from dimethyl malate via chiral phosphonates (4 and 5), were diastereoselectively reduced with Zn(BH4)2 to afford the 1, 3-syn derivatives (9 and 11). As an application of this 1, 3-asymmetric induction, the fungitoxic C-18 hydroxy unsaturated fatty acid isolated from stromata of Epichloe typhina was synthesized.
- 著者
- 樫原 宏 末宗 洋 常広 菜穂美 酒井 浄
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- Chemical & pharmaceutical bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.38, no.9, pp.2581-2582, 1990-09-25
The enones (II), which were obtained from dimethyl 4,5-isopropylidenedioxy-2-oxopentylphosphonate (Ia) and various aldehydes, were easily converted to 2-alkenylfurans (III) by treatment with p-TsOH in MeOH. In a similar manner, the furfuryl phosphonate (IVa) and the 3-methylfurfuryl phosphonate (IVb) were obtained from Ia and its 3-methylated analogue (Ib), respectively.
1 0 0 0 OA Novel Synthesis of Indan Derivatives
- 著者
- 樫原 宏 篠木 浩 末宗 洋 酒井 浄
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.34, no.11, pp.4527-4532, 1986-11-25 (Released:2008-03-31)
- 参考文献数
- 16
- 被引用文献数
- 6 11
During the course of synthetic studies on the 5, 6-disubsituted 4-oxo-tetrahydro-2-pyroneskeleton in connection with biologically active compounds, we have found a convenient procedure for the regioselective introduction of a double bond in methyl alkyl ketones and a novel synthetic method for indan derivatives.