Various kinds of 5'-O-unsaturated acyl 5-fluorouridines were synthesized to obtain 5-fluorouridine derivatives with low toxicity and high antitumor activity. Antitumor activity of the compounds against L-1210 leukemia in mice was examined, and the 5'-O-4-opentenoyl derivative showed the highest antitumor activity.
5-Fluorouracil Derivatives XX. : Synthesis and Antitumor Activity of 5'-O-Unsaturated Acyl-5-fluorouridines
尾崎 庄一郎, 星 昭夫
Ehime University
National Cancer Center Research Institute
Chemical and Pharmaceutical Bulletin
1990 年3166
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