著者
Naruhiko Sunada Hiroyuki Honda Yasuhiro Nakano Koichiro Yamamoto Kazuki Tokumasu Yasue Sakurada Yui Matsuda Toru Hasegawa Yuki Otsuka Mikako Obika Yoshihisa Hanayama Hideharu Hagiya Keigo Ueda Hitomi Kataoka Fumio Otsuka
出版者
The Japan Endocrine Society
雑誌
Endocrine Journal (ISSN:09188959)
巻号頁・発行日
pp.EJ22-0093, (Released:2022-04-28)
被引用文献数
26

Symptoms of long COVID are complex and long-lasting, and endocrine dysfunction might be involved in the underlying mechanisms. In this study, to clarify the hormonal characteristics of long COVID patients, laboratory data for patients who visited the outpatient clinic for long COVID were evaluated. A retrospective analysis was performed for patients who visited Okayama University Hospital during the period from Feb 2021 to Dec 2021 with focus on the interrelationships between major symptoms and endocrine data. Information and laboratory data were obtained from medical records for 186 patients. The patients had various symptoms, and the most frequent symptoms were general malaise, dysosmia/dysgeusia, hair loss, headache, dyspnea, and sleeplessness. Patients who were suffering from fatigue and dysosmia/dysgeusia were younger, while hair loss was more frequent in older and female patients. As for the characteristics of patients suffering from general fatigue, the scores of depression and fatigue were positively correlated with serum levels of cortisol and free thyroxin (FT4), respectively. Also, patients suffering from general fatigue had lower levels of serum growth hormone and higher levels of serum FT4, while patients with dysosmia/dysgeusia had a significantly lower level of serum cortisol. Serum thyrotropin (TSH) levels were higher and the ratios of FT4/TSH were lower in the initially severe cases, suggesting occult hypothyroidism. In addition, the ratios of plasma adrenocorticotropin to serum cortisol were decreased in patients with relatively high titers of serum SARS-CoV-2 antibody. Thus, hormonal changes seem to be, at least in part, involved in the persistent symptoms of long COVID.

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外部データベース (DOI)

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@VaxxDoc Hier de Japanse publicatie, is wel lap tekst btw. https://t.co/0ev3cDCELM
@vanranstmarc Wil je dit onderzoek ook meegeven. HPA axis etc, endocrinopathische bevindingen long covid. https://t.co/0ev3cDCELM
long covid endocrine bevindingen. btw zou ook de POTS verklaren, ivm adrenal cortex (hypoaldosteronism) long read. https://t.co/0ev3cDCELM
"Adult GH (growth hormone) deficiency is also an important disorder that causes general fatigue in patients who have hypothalamo-pituitary damage." This implies that the hypothalamus, a crucial centre of autonomic functions, is attacked by the virus. https://t.co/TtrA0DBpEo https://t.co/SGugoszVEa
As to186 patients who showed long COVID symptoms in 2021, "Patients who were suffering from fatigue and dysosmia/dysgeusia were younger, .. patients suffering from general fatigue had lower levels of serum growth hormone and higher levels of serum FT4." https://t.co/rcFqvUqceS
国内報告ですが、 コロナ後遺症の最も頻度の高い3つの症状は,全身倦怠感(52.2%)、感覚異常・味覚異常(43.0%)、脱毛(24.7%) 視床下部ー下垂体軸の中枢機能障害や甲状腺ホルモンなども症状に関与しているともいわれています。 後遺症の機序って難しいですよね。 https://t.co/vCvpTFMkGR https://t.co/L35mNJOZ1g
【(COVID-19 後遺症症状に見られるホルモン分泌変化に関する検討】 COVID-19罹患後症状は多彩であり、その原因は未だはっきりとしてないが、脳下垂体・副腎・甲状腺ホルモンなどの内分泌調節系の病態への関与が考えられている。 https://t.co/vCvpTG3nIR

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