著者
Minako Beppu Michi Kawamoto Souichi Nukuzuma Nobuo Kohara
出版者
The Japanese Society of Internal Medicine
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
vol.51, no.10, pp.1245-1247, 2012 (Released:2012-05-15)
参考文献数
12
被引用文献数
29 26

We describe a case of a 67-year-old man with systemic lupus erythematosus who presented with progressive left hemiplegia. Although the cerebral spinal fluid (CSF) polymerase chain reaction (PCR) for the JC virus was negative, a brain biopsy confirmed the diagnosis of progressive multifocal leukoencephalopathy (PML). The tapering of prednisone and the use of cidofovir could not arrest the disease progression. Administration of mefloquine stopped the extension of the lesion, and resulted in obvious clinical improvement. The CSF nested PCR for the JC virus also became negative. This widely used drug should be tried for the treatment of non-HIV PML.

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https://t.co/p3I8nOJqQr Mefloquine Improved Progressive Multifocal Leukoencephalopathy in a Patient with Systemic Lupus Erythematosus Minako Beppu, Michi Kawamoto, et al 日本でPML患者の治療に抗マラリア薬のメフロキンを使用したのは、岸田修二先生、川本未知先生、そして僕だった。

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