著者
大谷 真理子 山本 陽介 酒巻 智美 大沼 亜紀 赤木 圭太 松田 慶祐 杉山 奈津子 宮嶋 篤志 廣田 孝司 小茂田 昌代
出版者
一般社団法人日本医療薬学会
雑誌
医療薬学 (ISSN:1346342X)
巻号頁・発行日
vol.38, no.2, pp.78-86, 2012-02-10 (Released:2013-02-10)
参考文献数
9
被引用文献数
5 4

An oral scabicide, STROMECTOL® Tablets (ivermectin) is often administered to patients as a simple suspension by feeding tube. However, it was reported that the administration by this method was less effective than oral administration of tablets. One reason for this lower efficacy might be that the devices and technique for this method of administration are not appropriate. The aim of this study is to propose an appropriate technique.In this report, we compare the recovery ratio when a simple suspension is pushed through a syringe under various conditions. As a result of washing the syringe with distilled water after the first use, the recovery of ivermectin was higher than that without washing. The recovery of ivermectin from syringes set at an angle of 90° and 45° to the horizon was significantly higher than that at 0° and -45°. And recovery from previously used syringes was about 10% higher than that from new syringes (p<0.05). Furthermore, after having orally administered STROMECTOL® Tablets and gavaged its suspension with an appropriate delivery technique to rabbits, we measured the ivermectin concentrations in plasma by LC-MS/MS. The AUC0-192h of ivermectin was almost equivalent for both methods of administration.In conclusion, to secure the same dosage of administration with a simple suspension as that of tablets, it is highly recommended to employ a previously used syringe at an angle of over 45°, and to inject by a technique that washes out the entire residue in the syringe after first injection.

言及状況

外部データベース (DOI)

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本来、人間が持っている免疫力を正常化するから血中半減期を過ぎて体内から排出されても効果が持続する。となると、根本治癒に近いのかな。 東京理科大学薬学部の論文 簡易懸濁法の器具および手技が ストロメクトール®錠の投与量に及ぼす影響 https://t.co/KhEFX7MJuz 画像のグラフはウサギの実験 https://t.co/UtEAIeMJhN https://t.co/MazLsA7bP0
ストロメクトール(イベルメクチン)錠の投与量に及ぼす影響 東京理科大学薬学部の論文 https://t.co/3oGVzsUDR5 ウサギの実験でイベルメクチンが長く体内に留まる様子がわかります。 https://t.co/KVPypmlapx
イベルメクチン 3mg/ウサギ 濃度推移 長期間体内に留まるのがわかる。 脂質溶解性なので排出されにくい。 分解は肝臓で、ふん便で排出されるらしい。 https://t.co/eovbrGANTa https://t.co/0HliyQFR53

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