72 72 72 1 OA Immunohistochemical findings in the pancreatic islets of a patient with transfusional iron overload and diabetes: case report
- 著者
- Miyako Kishimoto Hisako Endo Shotaro Hagiwara Akiyoshi Miwa Mitsuhiko Noda
- 出版者
- The University of Tokushima Faculty of Medicine
- 雑誌
- The Journal of Medical Investigation (ISSN:13431420)
- 巻号頁・発行日
- vol.57, no.3,4, pp.345-349, 2010 (Released:2010-09-14)
- 参考文献数
- 11
- 被引用文献数
- 10 11
Excessive iron storage sometimes causes diabetes in patients with hemochromatosis, a disease caused by iron overloading. We performed an immunohistochemical analysis to study an autopsy case of aplastic anemia and diabetic hemochromatosis caused by frequent blood transfusions, and extensive hemosiderin deposition was observed in the liver and pancreas. The pancreatic islets of the patient and a control subject were stained to detect glucagon, insulin, and proinsulin. Significantly lower levels of immunoreactivity with both insulin antibodies and proinsulin antibodies, but not with glucagon antibodies, was observed in the islet cells in the patient’s tissue than in the islet cells of the control. Hemosiderin deposition in the islets is known to be exclusively distributed in the β-cells, thus, selective iron-induced damage to the β-cells may have affected insulin synthesis and secretion and led to glucose intolerance in the patient. J. Med. Invest. 57: 345-349, August, 2010
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接種後脂質ナノ粒子（LPN）の７５%は腕以外の体に分配される。そしてその内多くは脾臓に多くいく。そして脾臓でスパイク蛋白になるのであろう。そして、免疫との戦争後、過剰鉄分が脾臓に蓄積？過剰鉄分でベータ細胞が機能しなくインスリン抵抗。長期的には糖尿病。（仮説）
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