著者
Miyako Kishimoto Hisako Endo Shotaro Hagiwara Akiyoshi Miwa Mitsuhiko Noda
出版者
The University of Tokushima Faculty of Medicine
雑誌
The Journal of Medical Investigation (ISSN:13431420)
巻号頁・発行日
vol.57, no.3,4, pp.345-349, 2010 (Released:2010-09-14)
参考文献数
11
被引用文献数
10 11

Excessive iron storage sometimes causes diabetes in patients with hemochromatosis, a disease caused by iron overloading. We performed an immunohistochemical analysis to study an autopsy case of aplastic anemia and diabetic hemochromatosis caused by frequent blood transfusions, and extensive hemosiderin deposition was observed in the liver and pancreas. The pancreatic islets of the patient and a control subject were stained to detect glucagon, insulin, and proinsulin. Significantly lower levels of immunoreactivity with both insulin antibodies and proinsulin antibodies, but not with glucagon antibodies, was observed in the islet cells in the patient’s tissue than in the islet cells of the control. Hemosiderin deposition in the islets is known to be exclusively distributed in the β-cells, thus, selective iron-induced damage to the β-cells may have affected insulin synthesis and secretion and led to glucose intolerance in the patient. J. Med. Invest. 57: 345-349, August, 2010
著者
Yurika Numata‐Uematsu Hiroyuki Yokoyama Hiroki Sato Wakaba Endo Mitsugu Uematsu Chieko Nara Shigeo Kure
出版者
The University of Tokushima Faculty of Medicine
雑誌
The Journal of Medical Investigation (ISSN:13431420)
巻号頁・発行日
vol.65, no.3.4, pp.280-282, 2018 (Released:2018-10-04)
参考文献数
10
被引用文献数
10

Many studies have reported many adverse effects of children's use of media. These effects include reduced cognitive development and hyperactivity and attention disorders. Although it has been recommended that child be kept away from the media during the early developmental period, many modern parents use the media as a way to calm their children. Consequently, these children lack the opportunity to form selective attachments by reduced social engagement. These children's symptoms occasionally mimic autism spectrum disorder (ASD). However, few studies have examined the symptoms children develop with early media exposure. Here, we present a boy exposed to the media during his early development who was diagnosed with attachment disorder. He was unable to make eye contact and was hyperactive and had delayed language development, like children with ASD. His symptoms improved dramatically after he was prevented from using all media and encouraged to play in other ways. After this treatment, he would make eye contact, and talked about playing with their parents. Simply avoiding the media and playing with others can change the behavior of a child with ASD‐like symptoms. It is important to understand the symptoms caused by attachment disorder and early media exposure. J. Med. Invest. 65:280‐282, August, 2018
著者
Nobuto Nakanishi Takuya Takashima Jun Oto
出版者
The University of Tokushima Faculty of Medicine
雑誌
The Journal of Medical Investigation (ISSN:13431420)
巻号頁・発行日
vol.67, no.1.2, pp.1-10, 2020 (Released:2020-05-02)
参考文献数
114
被引用文献数
9

Critically ill patients exhibit prominent muscle atrophy, which occurs rapidly after ICU admission and leads to poor clinical outcomes. The extent of atrophy differs among muscles as follows: upper limb: 0.7%–2.4% per day, lower limb: 1.2%–3.0% per day, and diaphragm 1.1%–10.9% per day. This atrophy is caused by numerous risk factors such as inflammation, immobilization, nutrition, hyperglycemia, medication, and mechanical ventilation. Muscle atrophy should be monitored noninvasively by ultrasound at the bedside. Ultrasound can assess muscle mass in most patients, although physical assessment is limited to almost half of all critically ill patients due to impaired consciousness. Important strategies to prevent muscle atrophy are physical therapy and electrical muscular stimulation. Electrical muscular stimulation is especially effective for patients with limited physical therapy. Regarding diaphragm atrophy, mechanical ventilation should be adjusted to maintain spontaneous breathing and titrate inspiratory pressure. However, the sufficient timing and amount of nutritional intervention remain unclear. Further investigation is necessary to prevent muscle atrophy and improve long-term outcomes. J. Med. Invest. 67 : 1-10, February, 2020
著者
Rie Hashimoto Atsuko Sakai Masumi Murayama Arisa Ochi Tomoki Abe Katsuya Hirasaka Ayako Ohno Shigetada Teshima-Kondo Hiroaki Yanagawa Natsuo Yasui Mikiko Inatsugi Daisuke Doi Masanori Takeda Rie Mukai Junji Terao Takeshi Nikawa
出版者
The University of Tokushima Faculty of Medicine
雑誌
The Journal of Medical Investigation (ISSN:13431420)
巻号頁・発行日
vol.62, no.3.4, pp.177-183, 2015 (Released:2015-09-18)
参考文献数
20
被引用文献数
9 10

Background: In recent years, the number of bedridden people is rapidly increasing due to aging or lack of exercise in Japan. This problem is becoming more serious, since there is no countermeasure against it. In the present study, we designed to investigate whether dietary proteins, especially soy, had beneficial effects on skeletal muscle in 59 volunteers with various physical activities. Methods: We subjected 59 volunteers with various physical activities to meal intervention examination. Persons with low and high physical activities were divided into two dietary groups, the casein diet group and the soy diet group. They ate daily meals supplemented with 7.8 g of powdered casein or soy protein isolate every day for 30 days. Bedridden patients in hospitals were further divided into three dietary groups: the no supplementation diet group, the casein diet group and the soy diet group. They were also subjected to a blood test, a urinalysis, magnetic resonance imaging analysis and muscle strength test of the knee before and after the meal intervention study. Results: Thirty-day soy protein supplementation significantly increased skeletal muscle volume in participants with low physical activity, compared with 30-day casein protein supplementation. Both casein and soy protein supplementation increased the volume of quadriceps femoris muscle in bedridden patients. Consistently, soy protein significantly increased their extension power of the knee, compared with casein protein. Although casein protein increased skeletal muscle volume more than soy protein in bedridden patients, their muscle strength changes by soy protein supplementation were bigger than those by casein protein supplementation. Conclusions: The supplementation of soy protein would be one of the effective foods which prevent the skeletal muscle atrophy caused by immobilization or unloading. J. Med. Invest. 62: 177-183, August, 2015
著者
Tsuneo Ninomiya Hiroko Hashimoto Hiroe Tani Kenji Mori
出版者
The University of Tokushima Faculty of Medicine
雑誌
The Journal of Medical Investigation (ISSN:13431420)
巻号頁・発行日
vol.64, no.1.2, pp.153-159, 2017 (Released:2017-03-29)
参考文献数
12
被引用文献数
1 3

Objective: To improve primary prevention of child maltreatment, the association between at-risk parents identified by maternity hospitals and local health centers and intervention outcomes was investigated. Methods: A screening program for primary prevention of child maltreatment has been implemented for parents with children aged<3 years in A Prefecture. At-risk parents are identified at maternity hospitals and local health centers. Public health nurses provide intervention to promote positive parenting through home visits, and referred to child protective centers when they suspect child maltreatment. Results: Between 2009 and 2014, a total of 2,252 new at-risk parents were identified, 956 from maternity hospitals and 1,296 from local health centers. Among these at-risk parents, 356 (15.8%) were referred to child protective centers for possible child maltreatment, 88 of which came from maternity hospitals and 268 from local health centers. The rate of referral from maternity hospitals was significantly lower than that from local health centers (9.2% vs. 20.7%, p<0.001). Conclusions: Identification of at-risk parents during pregnancy and early intervention resulted in a decrease in the rate of referrals to child protective centers. The specific risk factors of “perceived lack of social support”, “mental illness” and “teen pregnancy” may be mitigated by early intervention. J. Med. Invest. 64: 153-159, February, 2017
著者
Michiko Sato Teruhiro Morishita Takafumi Katayama Shigeko Satomura Hiroko Okuno Nami Sumida Masae Sakuma Hidekazu Arai Shinsuke Katoh Koichi Sairyo Akihiko Kawaura Eiji Takeda
出版者
The University of Tokushima Faculty of Medicine
雑誌
The Journal of Medical Investigation (ISSN:13431420)
巻号頁・発行日
vol.67, no.1.2, pp.151-157, 2020 (Released:2020-05-02)
参考文献数
53
被引用文献数
4

A clearer understanding of skeletal muscle mass (SMM) in middle-aged and elderly individuals is important for maintaining functionality. In the present study, age-related changes in SMM, the threshold of SMM with walking difficulty, intestinal nutrient absorption rate, and various serum factors were examined in Japanese populations of different ages. We used 24-h creatinine excretion as a measure of total body SMM. Age-related decreases in SMM, intestinal nutrient absorption rates, and serum 25-hydroxyvitamin D [25(OH)D] concentrations were significantly higher in women than in men. The cut-off values for SMM (kg), its percentage of total body weight (BW), the SMM index [SMMI] (Kg / m2), and creatinine height index (CHI) (%) in elderly individuals with walking difficulty were approximately 8-10 kg, 17-20% of BW, 3.9-4.6 kg / m2, and 44%, respectively. Serum 25(OH)D concentrations were closely associated with SMM (kg, % of BW, kg / m2) and CHI (%) as well as the intestinal absorption rates of nitrogen (%) and phosphorus (%) in women, but not in men. The present results demonstrate that vitamin D is an important metabolic factor in skeletal muscle, and contributes to the optimal management of skeletal muscle and the prevention of sarcopenia. J. Med. Invest. 67 : 151-157, February, 2020
著者
Koichi Iwaki Toshinori Sakai Daisuke Hatayama Yohei Hayashi Nanae Inoue Miyuki Matsumoto Yusuke Hattori Tsuyoshi Goto Koichi Sairyo Shuichiro Tsuji
出版者
The University of Tokushima Faculty of Medicine
雑誌
The Journal of Medical Investigation (ISSN:13431420)
巻号頁・発行日
vol.65, no.3.4, pp.177-183, 2018 (Released:2018-10-04)
参考文献数
17
被引用文献数
1 2

The purpose of this study was to evaluate the physical features of pediatric patients with lumbar spondylolysis (LS), factors that increase the load during compensatory movements at the lumbar spine, and the outcomes of rehabilitation. Twenty patients were included. Fifteen items were used:fingertip‐to‐floor distance (FFD), straight leg raising (SLR), heel‐to‐buttock distance (HBD), tightness of the rectus femoris, the lateral and medial rotator muscles, iliopsoas, tensor fascia lata, adductor muscles, soleus muscle, and latissimus dorsi, and trunk rotation, sit‐ups and endurance of the abdominal and back muscles. Initial findings were judged as positive or negative using previously reported cut‐off values and were re‐evaluated 2 or 3 months later. Positive tests were found for HBD and tightness of the rectus femoris in 85% of the patients, for endurance of the abdominal muscles in 75%, SLR and sit‐ups in 70%, and FFD and tightness of the external rotator muscles in 60%. The physical features varied according to the type of sport played, and some patients were refractory to rehabilitation. Only 17.6%, 33.3%, and 40.0% of patients with initially positive findings for HBD, tightness of the external rotator muscles, and endurance of the abdominal muscles, respectively, achieved improvements after rehabilitation. J. Med. Invest. 65:177‐183, August, 2018
著者
Gen Adachi Tomoki Oshikawa Hiroshi Akuzawa Koji Kaneoka
出版者
The University of Tokushima Faculty of Medicine
雑誌
The Journal of Medical Investigation (ISSN:13431420)
巻号頁・発行日
vol.67, no.3.4, pp.274-279, 2020 (Released:2020-11-05)
参考文献数
32

The purpose of this study was to clarify the influence of different postures on the activity of the shoulder girdle and lower back muscles while using a smartphone. Sixteen healthy male participants maintained two postures while using a smartphone : a good posture in which the tragus and acromion were closer to the vertical line passing through the greater trochanter, and a poor posture in which the tragus and acromion were farther from the vertical line passing through the greater trochanter. The target muscles were the rhomboid major (Rhom), upper trapezius, middle trapezius, lower trapezius (LT), lumbar erector spinae (LES), and lumbar multifidus (LMF). The activities of the Rhom and LT were significantly lower with poor posture than those with good posture. The activities of LES and LMF were significantly higher with poor posture than those with good posture. The results of this study indicated that poor posture was associated with hypoactivity of the shoulder girdle muscles and hyperactivity of the lower back muscles when compared with good posture. Poor posture for prolonged periods while using a smartphone would lead to malfunction of the shoulder girdle muscles and musculofascial lower back pain. J. Med. Invest. 67 : 274-279, August, 2020
著者
Tomonori Watanabe Masahiro Nomura Kimiko Nakayasu Tomohito Kawano Susumu Ito Yutaka Nakaya
出版者
The University of Tokushima Faculty of Medicine
雑誌
The Journal of Medical Investigation (ISSN:13431420)
巻号頁・発行日
vol.53, no.1,2, pp.153-158, 2006 (Released:2006-03-11)
参考文献数
30
被引用文献数
11 11

Background: The thermic effect of food (TEF) is higher in lean than in obese human subjects.Objective: Relationships between TEF and insulin resistance during meals, from the point of view of autonomic nervous activity, were evaluated.Methods: Autonomic nervous activity was evaluated in 20 young adults using the spectral analysis of heart rate variability from one hour before to two hours after a meal. Heart rate data were analyzed based on low frequency components (LF power, 0.04-0.15 Hz), high frequency components (HF power, 0.15-0.40 Hz), and LF/HF ratios. Energy expenditure and the TEF were measured 30 min after a meal. Homeostasis model of insulin resistance index (HOMA-IR) was also measured.Results: The LF/HF ratio was significantly increased 30 min after a meal (p<0.05). No correlation between LF power and HF power with TEF was found, but the LF/HF ratio was significantly and positively correlated with TEF (r=+0.56, p<0.05). Moreover, a significant negative correlation was found between the HOMA-IR and TEF (r=-0.601, p<0.05).Conclusions: The findings suggest that a reduction in insulin sensitivity induces a poor response of sympathetic nervous activity in the postprandial phase and a reduction in postprandial energy expenditure. J. Med. Invest. 53: 153-158, February, 2006
著者
Taigo Horiguchi Yumiko Miyatake Keiko Miyoshi Ayako Tanimura Hiroko Hagita Hiroshi Sakaue Takafumi Noma
出版者
The University of Tokushima Faculty of Medicine
雑誌
The Journal of Medical Investigation (ISSN:13431420)
巻号頁・発行日
vol.67, no.1.2, pp.51-61, 2020 (Released:2020-05-02)
参考文献数
34

Spontaneously Running Tokushima Shikoku (SPORTS) rat is a hyperactive rat strain. However, the causative mutation of this phenotype has not yet been identified. To investigate the molecular basis for the unique phenotype of SPORTS rats, we examined gene-expression profiles by microarray analyses. Among adenylate kinase isozymes that maintain the homeostasis of cellular adenine nucleotide composition in the cell, only adenylate kinase 1 is highly up-regulated in both exercised and sedentary SPORTS rats compared with wild-type (WT) rats, 5.5-fold and 3.3-fold, respectively. Further comparative analyses revealed that genes involved in glucose metabolism were up-regulated in skeletal muscle tissue of exercised SPORTS rats compared with sedentary mutants, whereas genes related to extracellular matrix or region were down-regulated compared with WT rats. In brain tissue of sedentary SPORTS rats, genes associated with defense and catecholamine metabolism were highly expressed compared with WT rats. These findings suggest that genetic mutation(s) in SPORTS rat remodels metabolic demands through differentially regulating gene expression regardless of exercise. Therefore, the SPORTS rats are useful animal model not only for further examining the effects of exercise on metabolism but also for deeply studying the molecular basis how mutation affect the psychological motivation with spontaneous voluntary exercise phenotype. J. Med. Invest. 67 : 51-61, February, 2020
著者
Tohru Sakai Emi Shuto Tomoyo Taki Honami Imamura Miku Kioka Akiko Nakamoto Seiji Mizoguchi Shouko Amano Yukari Kawano Mariko Nakamoto Rie Tsutumi Toshio Hosaka
出版者
The University of Tokushima Faculty of Medicine
雑誌
The Journal of Medical Investigation (ISSN:13431420)
巻号頁・発行日
vol.59, no.1,2, pp.95-101, 2012 (Released:2012-03-08)
参考文献数
16
被引用文献数
1

NC/Nga (NC) mice are an animal model for human atopic dermatitis. We found that induction of antigen (Ag)-specific T cell response is diminished in ovalbumin (OVA)-immunized NC mice. Ability of Ag presentation in NC mouse dendritic cells (DCs) was significantly weaker than that in BALB/c and DBA/2 mouse DCs. Expression levels of MHC class II molecules and cathepsin E in NC mouse DCs were significantly lower that those in BALB/c and DBA/2 mouse DCs. These results indicate that low expression levels of MHC class II and cathepsin E might contribute to the defect in induction of Ag-specific T cells in NC mice. J. Med. Invest. 59: 95-101, February, 2012
著者
Masataka Kusunoki Kazuhiko Tsutsumi Meiho Nakayama Tsuyoshi Kurokawa Takao Nakamura Hitoshi Ogawa Yoshitaka Fukuzawa Munehiko Morishita Tatsuro Koide Tetsuro Miyata
出版者
The University of Tokushima Faculty of Medicine
雑誌
The Journal of Medical Investigation (ISSN:13431420)
巻号頁・発行日
vol.54, no.3,4, pp.243-247, 2007 (Released:2007-09-11)
参考文献数
15
被引用文献数
40 49

Background: Consumption of polyunsaturated fatty acids (PUFA) improves the lipid metabolism of diabetics, leading to prevents of arteriosclerosis. Exact relationship between saturated fatty acids (SFA) or PUFA and the insulin resistance of diabetics are unknown.Subjects and Methods: We investigated the relationship between the serum concentrations of saturated and unsaturated fatty acids and the homeostasis model insulin resistance index (HOMA-R) in Japanese patients with type 2 diabetes mellitus.Results: The SFA, i.e., lauric acid, myristic acid, palmitic acid, and stearic acid; the monounsaturated fatty acids (MUFA), i.e., palmitoleic acid, oleic acid, and erucic acid; and the PUFA, i.e., eicosadienoic acid, dihomo-γ-linolenic acid, docosatetraenoic acid, and docosapentaenoic acid were positively correlated with HOMA-R. However, no correlations were found between HOMA-R and SFA, i.e., arachidic acid, behenic acid, and lignoceric acid; the MUFA, i.e., eicosenoic acid and nervonic acid; and the PUFA, i.e., linoleic acid, γ-linolenic acid, linolenic acid, 5-8-11 eicosatrienoic acid, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid.Conclusions: Some PUFA as well as SFA were positively correlated with HOMA-R. These results indicate that the intake of diet fatty acid must be well balanced in diabetic patients and it is not always true to refrain from taking SFA and increase the unsaturated fatty acids in their diets. J. Med. Invest. 54: 243-247, August, 2007
著者
Joannes Paulus Tolentino Hernandez
出版者
The University of Tokushima Faculty of Medicine
雑誌
The Journal of Medical Investigation (ISSN:13431420)
巻号頁・発行日
vol.66, no.1.2, pp.24-30, 2019-02-15 (Released:2019-04-27)
参考文献数
52
被引用文献数
8

Telenursing is one type of telehealth service delivery proposed to resolve the predicted gap between healthcare workforce demand and supply globally. The aim of this article is to explore the ‘Nurse Chatbot' for chronic care on the benefits of increasing patient/client access to healthcare information and maximizing the potential of artificial intelligence/AI to bridge the ‘demand-supply gap' of human healthcare providers. Moreover,closing this gap through the establishment of a ‘Nurse Chatbot' will be innovative, favorably scalable and customizable within a decentralized health network, and potentially sustainable in the new digital economy. Following are the assumptions : 1) “caring” communicated textually is highly ‘transactive' in chronic disease selfmanagement support/CDSMS for goal agreements between agents and for overcoming the system noise in the form of cross-entropy, perplexity, and information wastage ; 2) ‘Nurse Chatbot' is the interlocutor in nursing care and the nursing agency by superpositioning and entanglement ; and 3) possible effects of chatbot-user transactions are information flows, management of health, and patient satisfaction. This article also looks into ‘Nurse Chatbot' development for CDSMS, simulation of its diffusion capacity egocentrically, technology acceptance model/TAM to inquire the engagement of users, and possible approaches to ethical and safety issues. J. Med. Invest. 66 : 24-30, February, 2019
著者
Freslyn Lim-Saco
出版者
The University of Tokushima Faculty of Medicine
雑誌
The Journal of Medical Investigation (ISSN:13431420)
巻号頁・発行日
vol.66, no.1.2, pp.8-11, 2019-02-15 (Released:2019-04-27)
参考文献数
17

Abstract : Theory development in nursing has been contentious so that issues about theory as knowledge base and counterpart of practice, and theory as the foundation of nursing as a discipline of knowledge and practice profession have facilitated the seeming ambiguity hindering theoretical contributions integral to human health and well-being. Nursing science continues to generate discussions about its development particularly grounding its practice as a legitimate component of human health care. The aims of this paper are (a) to describe three contemporary issues regarding theory construction and development in nursing, and (b) to advance a theory of nursing that can reconcile these issues. Content analysis following a review of literature revealed ontological,epistemological, and contextual issues on nursing theory development and theory-based practice perspective. The middle-range theory of Technological Competency as Caring in Nursing is advanced as integral to pursuing the reconciliation of theory development and practice engagements within the Universal Technological Domain in nursing and the health sciences. J. Med. Invest. 66 : 8-11, February, 2019
著者
Taijun Hana Junya Iwama Suguru Yokosako Chika Yoshimura Naoyuki Arai Yasuhiro Kuroi Hirokazu Koseki Mami Akiyama Kengo Hirota Hidenori Ohbuchi Shinji Hagiwara Shigeru Tani Atsushi Sasahara Hidetoshi Kasuya
出版者
The University of Tokushima Faculty of Medicine
雑誌
The Journal of Medical Investigation (ISSN:13431420)
巻号頁・発行日
vol.61, no.1.2, pp.41-45, 2014 (Released:2014-04-04)
参考文献数
21
被引用文献数
7 9

We aimed to determine the sensitivity of CT perfusion (CTP) for the diagnosis of cerebral infarction in the acute stage. We retrospectively reviewed patients with ischemic stroke who underwent brain CTP on arrival and MRI-diffusion weighted image (DWI) after hospitalization between October 2008 and October 2011. Final diagnosis was made from MRI-DWI findings and 87 patients were identified. Fifty-five out of 87 patients (63%) could be diagnosed with cerebral infarction by initial CTP. The sensitivity depends on the area size (s): 29% for S < 3 cm2, 83% for S ≥ 3 cm2 - < 6 cm2, 88% for S ≥ 6 cm2 - < 9 cm2, 80% for S ≥ 9 cm2 - < 12 cm2, and 96% for S ≥ 12 cm2 (p < 0.001). Sensitivity depends on the type of infarction: 0% for lacunar, 74% for atherothrombotic, and 92% for cardioembolism (p < 0.001). Sensitivity is not correlated with hours after onset. CT perfusion is an effective imaging modality for the diagnosis and treatment decisions for acute stroke, particularly more serious strokes. J. Med. Invest. 61: 41-45, February, 2014
著者
Kawai Yoshichika
出版者
The University of Tokushima Faculty of Medicine
雑誌
The Journal of Medical Investigation (ISSN:13431420)
巻号頁・発行日
vol.65, no.3.4, pp.162-165, 2018 (Released:2018-10-04)
参考文献数
28
被引用文献数
12

Many papers have suggested the health‐beneficial activity of natural dietary polyphenols to prevent chronic diseases and aging processes in humans. It is generally recognized that polyphenols are absorbed from the intestines and metabolized into the phase‐Ⅱ conjugates, i.e., the glucuronides and sulfates. For example, a major dietary flavonoid, quercetin, abundant in onion and buckwheat, is metabolized after oral intake into its conjugates, such as quercetin‐3‐O‐glucuronide and quercetin‐3'‐O‐sulfate, whereas no aglycone was found in the human plasma. Therefore, to understand the mechanisms of the biological activity of quercetin in vivo, we should focus on the molecular actions of these conjugates. In the last decade, we have demonstrated the unique actions of quercetin‐3‐O‐glucuronide at sites of inflammation, including specific accumulation in macrophages and the following deconjugation into active aglycone, catalyzed by the macrophage‐derived β‐glucuronidase. This review summarizes recent findings regarding the anti‐inflammatory mechanisms of quercetin conjugates in macrophages and propose a possible strategy for the effective utilization of natural polyphenols in our daily diet for prevention of age‐related chronic diseases. J. Med. Invest. 65:162‐165, August, 2018
著者
Machiko Kiyokawa Toshiya Matsuzaki Takeshi Iwasa Rie Ogata Masahiro Murakami Riyo Kinouchi Shinobu Yoshida Akira Kuwahara Toshiyuki Yasui Minoru Irahara
出版者
The University of Tokushima Faculty of Medicine
雑誌
The Journal of Medical Investigation (ISSN:13431420)
巻号頁・発行日
vol.58, no.1,2, pp.11-18, 2011 (Released:2011-03-01)
参考文献数
28
被引用文献数
5 8

Objectives: Reproductive functions are influenced by various feeding regulators. Orexin, which is one of orexinergic peptides, suppresses the pulsatile secretion of luteinizing hormone (LH) in bilaterally ovariectomized (OVX) rats. However, the mechanism of this effect is still not clear. To investigate whether neuropeptide Y (NPY) is involved in the orexin A-mediated suppression of pulsatile LH secretion, we evaluated the effects of NPY antibody on the suppressive effect of orexin A. Methods: Orexin A was administered intracerebroventricularly (icv) and NPY antibody (NPY-Ab) was injected before icv administration of orexin A in OVX rats. Pulsatile LH secretion was analyzed by measuring serum LH concentrations in the next 2 h in blood samples drawn at 6-min intervals by radioimmunoassay. Results: Administration of orexin A significantly reduced the mean LH concentration and LH pulse frequency. Co-administration of NPY antibody with orexin A significantly restored the suppressive effect of orexin A on the mean LH concentration and LH pulse frequency. Conclusion: NPY mediated the suppressive effect of intracerebroventricularly injected orexin A on pulsatile LH secretion, suggesting that hypothalamic orexin suppressed pulsatile gonadotropin-releasing hormone (GnRH) secretion via NPY in the hypothalamus of female rats. J. Med. Invest. 58: 11-18, February, 2011
著者
Hideyuki Nemoto Kazue Ikata Hideki Arimochi Teruaki Iwasaki Yoshinari Ohnishi Tomomi Kuwahara Keiko Kataoka
出版者
The University of Tokushima Faculty of Medicine
雑誌
The Journal of Medical Investigation (ISSN:13431420)
巻号頁・発行日
vol.58, no.3,4, pp.235-245, 2011 (Released:2011-09-16)
参考文献数
35
被引用文献数
16

The aim of this study is to investigate the prebiotic effects of brown rice fermented by Aspergillus oryzae (FBRA) on the intestinal environment in vitro and in healthy adults. Methods: Fresh fecal slurries from six healthy adults were incubated with FBRA to confirm prebiotic potentials of FBRA. Another thirty-six healthy adults were randomly allocated to 2 groups for the clinical study. Subjects consumed 21.0 g/day of either FBRA or control food for 2 weeks, followed by a 12-week intermission and then 2-week ingestion vice versa. Main outcome measures were bifidobacterial numbers and organic acid concentration in feces. Sub outcome measures were fecal microbiota, fecal environments and bowel function. Results: Incubation of fecal slurries with FBRA in vitro resulted in increased organic acids with individual-specific patterns. Bifidobacterial numbers were increased during incubation. In the clinical study, all participants safely completed this study. FBRA had little effect on fecal number of bifidobacteria, concentrations of organic acids or putrefactive metabolites, fecal pH, or fecal microbiota. Conclusion: FBRA has the potentials as a prebiotic, however, we could not detect its effects on the intestinal environment in vivo. The results in a clinical study indicated that FBRA could be safely used for healthy adults. J. Med. Invest. 58: 235-245, August, 2011
著者
Tohru Sakai Mari Kogiso
出版者
The University of Tokushima Faculty of Medicine
雑誌
The Journal of Medical Investigation (ISSN:13431420)
巻号頁・発行日
vol.55, no.3,4, pp.167-173, 2008 (Released:2008-09-17)
参考文献数
38
被引用文献数
80

The amount of soy products consumed in Japan is much greater than that in Western countries. Recent evidence indicates that soy isoflavones play a beneficial role in obesity, cancer, osteoporosis, and cardiovascular disease. The soybean isoflavone genistein is present at high levels in soy products. Genistein is structurally similar to 17β-estradiol (E2), and genistein has been suggested to be act as E2 or an antagonist against E2. Genistein suppresses antigen-specific immune response in vivo and lymphocyte proliferation response in vitro. However, genistein enhances the cytotoxic response mediated by NK and cytotoxic T cells and the cytokine production from T cells. Thus, the effect of genistein on immunity is immune cell-dependent. Due to its unique effect on immune function, genistein has been used for the treatment of the diseases in animal models and it has been found that genistein inhibits allergic inflammatory responses. In this review, we summarize current studies related to the effect of isoflavone genistein on the immune system. J. Med. Invest. 55: 167-173, August, 2008