著者
Akihiro Tanaka Katsuya Suemaru Hiroaki Araki
出版者
The Japanese Pharmacological Society
雑誌
Journal of Pharmacological Sciences (ISSN:13478613)
巻号頁・発行日
vol.105, no.1, pp.1-5, 2007 (Released:2007-09-20)
参考文献数
27
被引用文献数
34 32

In clinical practice, the measurement of endogenous serum substances in order to estimate glomerular filtration rate (GFR) is commonly performed, and the serum creatinine level has become the most commonly used serum marker of renal function. However, the measurement of the serum creatinine concentration can sometimes lead to an overestimation of GFR, especially in the elderly. In recent years, it has been suggested that GFR can be predicted based on the serum cystatin C concentrations and that the serum cystatin C concentration is not influenced by gender or age. A recent meta-analysis demonstrated that serum cystatin C is a better marker for GFR than serum creatinine. In clinical practice, it has been suggested that serum cystatin C can optimize early detection for diabetic or hypertensive nephropathy. In addition, the use of serum cystatin C is possibly more appropriate for establishing an appropriate dose adjustment of drugs that are mainly eliminated by the kidney.

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fig1 クレアチニン値は加齢とともに上昇するとは限らない。筋肉量は減るので https://t.co/IX7v8GQQe2
【S03】 #jsphcs2020 https://t.co/nzBd9w8n0z https://t.co/gAdLqIocNf https://t.co/IFiee0XpeO

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