著者

小野 裕子

出版者

日本酪農科学会

雑誌

ミルクサイエンス (ISSN:13430289)

巻号頁・発行日

vol.61, no.1, pp.33-40, 2012 (Released:2014-03-15)

参考文献数

54

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Sphingomyelin (SPM) is a major lipid of bovine milk fat globules and has been attractive in its biological functions. In the epidermis, SPM is a precursor of the biosynthesis of ceramides that play a crucial role in the retention of water and permeability barrier. However, the effect of orally administrated SPM on epidermal function is poorly understood. We investigated the effect of SPM concentrate prepared from bovine milk on the water retaining function in the epidermis by the animal study and the clinical test. Thirteen week-old hairless mice were fed SPM concentrate diets for six weeks. The results showed that 504 mg/day intake of SPM concentrate improved epidermal hydration, transepidermal water loss and ceramides content. We found that 17 mg/day intake of SPM concentrate was enough to prevent water loss and retain water in the epidermis of hairless mice. A placebo-controlled randomized double-blind clinical study of the oral intake was investigated on 25 individuals. The soft capsules containing 330 mg/day of SPM concentrate were administrated to subjects for six weeks. The placebo was prepared with the same amount of phospholipids from soy beans. SPM concentrate group showed significantly higher epidermal hydration than the placebo group. The sebum amount on the skin surface tended to be higher than that of the placebo group. Subjective symptom also revealed that reflectance and elasticity were improved in SPM concentrate group. These results indicate that dietary SPM concentrate improves the water retaining function in the epidermis, and is useful for maintaining the integrity of healthy skin.