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Ronald M. Chavin (@rmchavin)

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1 0 0 0 OA Kuanoniamine C Suppresses Adipogenesis and White Adipose Tissue Expansion by Modulating Mitochondrial Function

Shikoku, Japan: Obesity gets worse if white adipose tissue increases while brown adipose tissue decreases. The anti-obesity pyridoacridine alkaloid, kuanoniamine C, was called in to rescue mice from insulin-, IBMX-, and dexamethasone-induced adipogenesis: https://t.co/pfHZZrs1hY

3 0 0 0 OA Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement

Society's obsession with narrow-spectrum antivirals called, 3CL protease inhibitors, continues. They all: *Will end up being swallowed on Day 5, not Day 1 as they need to be *Lose efficacy with viral evolution *Can't be used against the flu *Pro-oxidants https://t.co/vzMxMjqEyH

1 0 0 0 OA Endothelial Damage-dominant Nephritis Related to IgA Vasculitis after 11 Years' Use of Infliximab for Rheumatoid Arthritis

After Remicade (infliximab) & methotrexate had failed, Actemra (tocilizumab) was called in to rescue a 43-year old lady, both from RA & from drug-induced proteinuria, purpura, & endothelial damage-dominant nephritis with IgA deposition. Was it too late?? https://t.co/MQNZlUgPdf

1 0 0 0 OA Severe TAFRO Syndrome Mimicking Hepatorenal Syndrome Successfully Treated with a Multidisciplinary Approach: A Case Report and Literature Review

12-19-22: Kyoto, Japan: Corticosteroids, cyclosporin, & Actemra (tocilizumab) rescued a 60-year old man from severe, grade 5 TAFRO syndrome mimicking hepatorenal syndrome & a virus infection...inflammation, renal dysfunction, & thrombocytopenia improved" https://t.co/fhICU0Ba1m

1 0 0 0 OA Rapid Clinical Improvement of Multicentric Castleman Disease (MCD) with Renal Involvement Following Treatment with Tocilizumab: AA Amyloidosis as a Possible Renal Involvement of MCD

9-19-2022: Fukushima, Japan: After other treatments had failed, Actemra (tocilizumab) was called in to rescue somebody from MCD complicated by AA amyloidosis: https://t.co/R6UWmcYKEq https://t.co/2XdCI0D84h https://t.co/ZHgg68wu7I https://t.co/yec24hECe1 https://t.co/G4XJss51zJ

1 0 0 0 OA Encapsulating Peritoneal Sclerosis in Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Systemic Sclerosis

3-18-22: Saitama, Japan: Actemra (tocilizumab) was called in to rescue a 57-year-old lady from encapsulating peritoneal sclerosis (EPS), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis, & ascites retention; died in 1 year https://t.co/MuqhVHDiFQ https://t.co/V8tJIOsCNk

1 0 0 0 OA The Assessment of the Efficacy and Safety of Favipiravir for Patients with SARS-CoV-2 Infection: A Multicenter Non-randomized, Uncontrolled Single-arm Prospective Study

3-2-2022: Gunma & Saitama, Japan: Pro-favipiravir study in which the slightly higher dose (Group 2) performed much better than the slightly lower dose (Group 1). Next, try an even higher dose than Group 2 for even better results: https://t.co/6gcwXwdrwy https://t.co/uskOzxSpWM

1 0 0 0 OA Antiviral susceptibilities of avian influenza A(H5), A(H7), and A(H9) viruses isolated in Japan

10-26-2021: New study from Japan: although other antivirals can be used in animals for deadly avian influenza, only the safest can be used in humans at double the COVID-19 dosages: https://t.co/cYgpzdADKJ https://t.co/uPez4RJp46 https://t.co/iqA0KJuxCs https://t.co/iBSYhGZcWT