著者

早川 一郎

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 : JOURNAL OF Synthetic Organic Chemistry JAPAN (ISSN:00379980)

巻号頁・発行日

vol.65, no.12, pp.1225-1226, 2007-12-01

参考文献数

9

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Halichondrin B is a polyether macrolide that exhibits an extraordinary cytotoxicity <I>in vitro</I> and antitumor efficacy <I>in vivo</I>. A structurally simplified macrolactone right half segment of harichondrin B was identified to retain the potent cell growth inhibitory activity of the natural product <I>in vitro</I>. Kishi and coworkers developed a practical, an efficient and scalable synthesis of the right half segment of harichondrin B.