著者

伊東 明彦 小林 由美子 杉原 正泰

出版者

日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.15, no.1, pp.5-10, 1989-02-20

被引用文献数

1

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The significance of depth of score, the kinds of binders and granules for compression on dividing of scored tablets was investigated. Scored tablets with the rate of depth of score per thickness varying with 10, 20 and 30% were prepared using hydroxypropylcellulose (HPC), potato starch, acacia and gelatin as binder and sieved granules in three particle sizes and no sieved granules as granules for compression. Dividing strength of the scored tablets decreased with an increase in depth of score and was affected by the kinds of binders. Weight variation of the divided tablets was the smallest on the tablet of 30% depth of score prepared from sieved granules irrespective of the kinds of binders and physical characteristics of granules. However, when the rate of depth was lower than 20%, the weight variation of the divided tablets was affected by the kinds of binders and physical characteristics of the granules. With 20% depth of score, tablets using potato starch and gelatin as binder showed little weight variation. In case of the 10%, tablets using potato starch and granules of 16-32 mesh showed better results. Tablets prepared with non-sieved granules showed effect of particle size distribution of granules on weight variation of divided tablets even in the case of the 30% depth.