著者

田中 公夫 鎌田 七男 大北 威 蔵本 淳

出版者

日本放射線影響学会

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.24, no.4, pp.291-304, 1983-12

被引用文献数

1 25

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The distribution of breakpoints within chromosomes in lymphocytes of 39 healthy atomic bomb survivors who were heavily exposed were studied by means of G- and Q-banding techniques. A total of 1,414 breakpoints in 651 cells with structural chromosome aberrations were used for the present analyses. The results obtained were as follows: (1) In chromosomes #15, #18 and #22, the breaks were more frequently observed than expected. On the contrary, the number of breaks among chromosomes #1, #2 and X was less than expected. (2) A higher incidence of breakpoints according to the length of regions in 4q3, 5q3 and 14q3 and a lower incidence in regions around centromeres of large chromosomes were observed. (3) Distribution of breakpoints was 26.6% in the centromeric region, 30.8% in the middle region and 42.6% in the telomeric region. (4) Seventy-four percent of the breaks was observed in the negative bands.