著者

植木 昭和

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.103, no.9, pp.909-921, 1983-09-25

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Characteristics of aggressive behavior induced in rats by olfactory bulbectomy, midbrain raphe lesions, nucleus accumbens septi lesions and an administration of Δ^9-tetrahydrocannabinol were compared and the effects of various drugs were investigated in details. Defensive aggression of these rats was readily inhibited by neuroleptics and antianxiety drugs, while muricide (mouse-killing behavior) was selectively suppressed by antidepressants, indicating that muricide of the rat would be a good animal model for depressive illness. It was also clarified that the neural mechanism for inducing muricide and the response to antidepressants differed each other depending upon the method of muricide induction. It is suggested that these various types of muricide are useful in evaluating the mechanisms of action of antidepressants.