著者

山田 敏広 山下 武彦 中村 正則 嶋村 浩 山口 東 高谷 昌弘

出版者

公益社団法人日本薬学会

雑誌

薬学雑誌 (ISSN:00316903)

巻号頁・発行日

vol.100, no.8, pp.p799-806, 1980-08

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In order to obtain more hydrophylic and more potent hemostatics, 2-semicarbazono-1,2-naphthoquinone analogs with or without sulfonic acid or its salts at 4,5,6,7 or 8 position (III and IV) and 4-semicarbazido-1,2-naphthoquinone analogs (V) were prepared and their hemostatic activities and acute toxicities were examined. Among these compounds, more hydrophilic 2-semicarbazono-1,2-naphthoquinone analogs with sulfonic acid group (IIIj and IIIr) as well as less hydrophilic 2-semicarbazono-1,2-naphthoquinones without sulfonic acid group (IVa and IVh) and 4-semicarbazido-1,2-naphthoquinone analogs (Ve) showed the activity comparable to that of 2-semicarbazono-1,2-naphthoquinone (II) or carbazochrome sodium sulfonate (I) in shortening the bleeding time.