- 著者
-
山田 敏広
山下 武彦
中村 正則
嶋村 浩
山口 東
高谷 昌弘
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- 薬学雑誌 (ISSN:00316903)
- 巻号頁・発行日
- vol.100, no.8, pp.p799-806, 1980-08
In order to obtain more hydrophylic and more potent hemostatics, 2-semicarbazono-1,2-naphthoquinone analogs with or without sulfonic acid or its salts at 4,5,6,7 or 8 position (III and IV) and 4-semicarbazido-1,2-naphthoquinone analogs (V) were prepared and their hemostatic activities and acute toxicities were examined. Among these compounds, more hydrophilic 2-semicarbazono-1,2-naphthoquinone analogs with sulfonic acid group (IIIj and IIIr) as well as less hydrophilic 2-semicarbazono-1,2-naphthoquinones without sulfonic acid group (IVa and IVh) and 4-semicarbazido-1,2-naphthoquinone analogs (Ve) showed the activity comparable to that of 2-semicarbazono-1,2-naphthoquinone (II) or carbazochrome sodium sulfonate (I) in shortening the bleeding time.