著者
青山 みさ子 四童子 好廣 山口 義彦 貞森 直樹
出版者
公益社団法人 日本ビタミン学会
雑誌
ビタミン (ISSN:0006386X)
巻号頁・発行日
vol.82, no.3, pp.179-185, 2008
参考文献数
11

Single-nucleotide polymorphisms (SNPs) of the mitochondrial NADH dehydrogenase subunit-2 (ND2) andβ3-adrenergic receptor (BAR3) genes are well established to be associated with life style-related diseases. The ND2 gene variant (Mt5178A) is associated with longevity or less susceptibility to adult-onset diseases. The BAR3 gene allelic variant (Trp64Arg and Arg64Arg) is linked with obesity or non-insulin-dependent diabetes mellitus. We investigated whether the combination of these 2 genes affect eating behavior, and found that the BAR3-normal (Trp64Trp)+ND2-variant (Mt5178A) group preferred much carbohydrate and less animal protein, Vitamin B_2 (B_<2)>, calcium in comparison with the other genetic groups. Less intake of B_2 was principally associated with Mt5178A in this group. Taking account that flavin adenine dinucleotide is a coenzyme of the NADH dehydrogenase which composes the proton-pumping complex I of the mitochondrial electron transport system, the association between Mt5178A variant and less B_2 intake is tremendously interesting. In this paper, we discuss a possible association between genetic polymorphism and eating behavior by summarizing our own research data.

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CiNii 論文 -  ミトコンドリアNADH脱水素酵素サブユニット2遺伝子多型とビタミンB_2要求性 https://t.co/gNkw0m68Bs #CiNii

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