著者

竹口 紀晃

出版者

The Biophysical Society of Japan General Incorporated Association

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.23, no.6, pp.283-290, 1983

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Fluxes of ions such as H<SUP>+</SUP>, Cl<SUP>-</SUP>, K<SUP>+</SUP>, Na<SUP>+</SUP>, and HCO<SUB>3</SUB><SUP>-</SUP> in the parietal cell are summarized. Gastric vesicles containing membrane (H<SUP>+</SUP>+K<SUP>+</SUP>)-ATPase are isolated from the parietal cell and can accumulate H<SUP>+</SUP> in exchange for K<SUP>+</SUP> (H<SUP>+</SUP>/K<SUP>+</SUP> antiport, nonelectrogenic) on the addition of MgATP. The intravesicular pH falls as low as 1-3, dependending on the methods used for estimation. The biochemical properties of the ATPase are summarized. Onset of acid secretion changes the morphology of the parietal cell at the secretory surface. This is explained by the increase in KCl conductance of gastric vesicle membrane. The increase is due to the opening of the anion channel caused by S-S cross-linkings.