著者

新井 和孝

出版者

社団法人 有機合成化学協会

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.44, no.6, pp.486-498, 1986

被引用文献数

8

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In recent years, synthetic method by the combination of isomerization and crystallization is studied intensively, especially in the practical optical resolution. In this paper, this isomerization-crystallization method is introduced from a point of view of practical organic synthesis. A number of examples of this isomerization-crystallization method in optical resolution, many of which were often reported as the example of second-order asymmetric transformation phenomena, are classified into following two groups, and reviewed.<BR>(1) Epimerization-crystallization method.<BR>(2) Racemization-preferential crystallization method.<BR>The potentialities and difficulities of each method are also discussed. The compounds resolved by this methods are &alpha;-amino acid derivatives, cyanohydrin derivatives, &alpha;-aromatic carboxylic acid esters, and so on.