著者

大山 建司

出版者

日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.55, no.5, pp.657-677, 1979

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The subjects were 36 neonates who had had no abnormalities at gestation or at birth. In 9 of the 36 neonates, exchange transfusions were performed by umbilical vein catheterization. The others had no abnormalities during the neonatal period. They consisted of 17 male and 19 female infants who were from 39-42 weeks of gestation and weighed 2870-3900g at birth. Serum GH, TSH, LH and FSH were measured by radioimmunoassay during the exchange transfusions, and after the administration of TRH or LH-RH in the early neonatal period. Furthermore, serum GH was measured after glucose administration. The following results were obtained.<BR>1) Serum GH increased in 7 out of 8 neonates, corresponding to continuous hyperglycemia during the exchange transfusion. It also increased in one out of 4 neonates, corresponding to transient hyperglycemia after the glucose administration.<BR>2) Serum GH after the TRH administration decreased in all of six neonates during the first 120 hours after birth but increased in 3 of four neonates during 7 to 10 days after birth.<BR>3) Serum GH after the LH-RH administration increased in 4 out of six neonates.<BR>4) Serum TSH showed no significant changes by either the exchange transfusion or the administration of LH-RH in the early neonatal period.<BR>5) When TRH was given to 5 neonates during 96 hours after birth, the serum TSH response was exaggerated and prolonged. In 6 neonates of 96 hours to 15 days after birth, serum TSH response to TRH was the same as that in normal infants.<BR>6) Serum T<SUB>3</SUB> increased 60 to 90 minutes after the TRH administration in all 5 neonates.<BR>7) During the exchange transfusion, serum LH definitely increased in 3 out of five male neonates, but serum FSH remained unchanged at a low level in all the male neonates. Serum LH did not increase in all the 3 female neonates, but in 2 of them serum FSH increased.<BR>8) Serum LH after the TRH administration increased in 3 out of four males and 4 out of six neonates. On the other hand, serum FSH remained unchanged in both male and female neonates.<BR>9) Serum LH response to LH-RH was higher in male (especially in more than 6-day-old neonates) than in female neonates. Serum FSH after the LH-RH administration increased in female neonates but did not increase in male neonates.<BR>The results mentioned above suggest the immaturity of the secretory controlling mechanism of GH, LH and FSH in the hypothalamo-pituitary system. However, the secretory mechanism of TSH appears to function independently of the other secretory systems, because serum TSH levels were not influenced by the exchange transfusion and LH-RH administration. In the hypothalamo-pituitary-gonadal system, secretion of LH appears to be predominant in males while that of FSH appears to be predominant in females even in the early neonatal period.