著者

田波 洋 山田 喜紹

出版者

日本ウイルス学会

雑誌

ウイルス (ISSN:00426857)

巻号頁・発行日

vol.14, no.3, pp.103-109, 1964

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Life cycle of goat pneumonitis agent, strain Nagano, in L cell culture was described. The developmental cycle occurs in four stages, as generally observed with PLT group of agents: (i) penetration of invaded elementary bodies into the cytoplasm. (ii) transformation of the elementary bodies to the initial bodies occurs by the 8th hour after inoculation. (iii) Initial bodies begin to multiply between the 11th and 12th hours as observed by appearance of the &ldquo;diplococci-like&rdquo; forms. Thereafter they multiply at an exponential rate, and (iv) highly infective mature particles are formed after the 21st hour. The life cycle is complete in 48 hours.<br>The results are well accounted for as that the invaded elementary bodies transform directly to the initial bodies, the vegetative forms, from which highly infective elementary bodies are developed. Which rules out the possibility that the multiplication of the agent might occur at a (hypothetical) preliminary virus-like phase, before the formation of the initial bodies.