著者
山縣 邦弘 小山 哲夫 小林 正貴 成田 光陽
出版者
Japanese Society of Nephrology
雑誌
日本腎臓学会誌 (ISSN:03852385)
巻号頁・発行日
vol.32, no.10, pp.1045-1052, 1990

This study was undertaken to analyze the mechanisms of immune complex formation in Heymann nephritis. We isolated two different RTE antigens by gel filtration and prepared rabbit antisera against these antigens. By the indirect immunoflurescence method using normal rat renal tissues, the 65, 000 molecular weight antigen (=β) was observed not only in RTE, but also in the glomerular epithelium, epithelium of the small intestine, liver and spleen. On the other hand, the 35, 000 molecular weight antigen (=γ) existed in RTE and epithelium of the small intestine. When rats were injected intravenously with rabbit antiserum against β, glomerular depositions were observed within two hours. In rats injected with rabbit antiserum against r, no glomerular deposition was seen with-in 2 days, but fine granular depositions were observed after 6 days. When rat kidneys were perfused with rabbit antiserum against γ in saline by a single pass method, no glomerular deposition was seen. However, in rat kidneys perfused with preformed soluble γ-anti γ IC, fine granular depositions along the capillary walls were seen soon after the perfusion. Further the antigen which was reacted with anti γ antiserum was isolated from normal rat serum by immuno-affinity chromatography. These facts suggest that the mechanisms of IC formation may be due to not only in situ immune complex formation but also circulating immune complex deposition in Heymann nephritis.

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こんな論文どうですか? 受身ヘイマン腎炎における免疫複合体の沈着様式 プロナーゼ処理ラット腎尿細管刷子縁抗原を用いての検討:―プロナーゼ処理ラット腎尿細管刷子縁抗原を用いての検討―(山縣 邦弘ほか),1990 … https://t.co/B8qhu9pCbk

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