著者

里見 信子 原中 勝征 国井 乙彦 真下 啓明

出版者

一般社団法人 日本感染症学会

雑誌

感染症学雑誌 (ISSN:03875911)

巻号頁・発行日

vol.53, no.8, pp.350-358, 1979

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In OEP (common protective antigen of <I>Pseudomonas aeruginosa</I>) immunized mice, OEP-HA (hemagglutination) titer was decreased by intraperitoneal inoculation of <I>P. aeruginosa</I>, especially Fisher's serotype 2 and NC 5 strain. All of OEP immunized mice survived from the challenges by Fisher's seven serotypes strains. Otherwise all of non-immunized mice died within 48 hours by seven serotypes challenges.<BR><I>In vitro</I> system, the enhancing effects of the phagocytosis of mice spleen macrophages by anti-OEP-antibody were common to all of Fisher's seven serotype, and the decreasing tendancy of OEP-HA titer in these supernatants was observed.<BR>The OEP-HA titer and Formalized bacterial agglutination titer were measured in various &gamma;-globulin products before and after the absorption by OEP antigen. Only in Fisher's serotype 2 and NC 5 strains their titer was decreased.<BR>By injection of &gamma;-globulin products to mice, serum &gamma;-globulin concentration and OEP-HA titer were increased a little, but their therapeutic effectiveness to <I>P. aeruginosa</I> infection was reavealed in our previous reports.<BR>When &gamma;-globulin products were absorbed with OEP antigen, their therapeutic effects were depressed.<BR>In conclution, anti-OEP-antibody has therapeutic effect to the all of Fisher's serotypes of <I>P. aeruginosa</I> infection and the hig h level of antibody in bloo d is not always needed fo r the immunotherapy.