著者

青野 要 山本 道夫 飯田 荘介 内海 耕慥

出版者

岡山医学会

雑誌

岡山医学会雑誌 (ISSN:00301558)

巻号頁・発行日

vol.90, no.9, pp.1297-1308, 1978

被引用文献数

1

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In relation to the mechanism by which hemolysis was induced in radiated human erythrocytes <i>in vitro</i>, several inducements of membrane lipid peroxidation and protective effects of V. E and SOD were investigated. Results obtained were as follows:<br>(1) K⁺-release from erythrocytes was accelerated by radiation prior to hemolysis. These accelerated hemolysis and K⁺-release were protected remarkably by V. E and evidently by SOD.<br>(2) Mitochondrial Fe²⁺ induced and Fe³⁺-O₂ generating system - ADP induced lipid peroxidation, and microsomal O₂ generating system - induced lipid peroxidation were also protected by V. E and SOD.<br>(3) Radiation of X-ray or ⁶⁰Co &gamma;-ray accelerated lipid peroxidation of liver homogenate, microsome and liposome. Some of these accelerated lipid peroxidations were protected effectively by V. E and SOD.<br>These results suggest that O₂ and/or OH&middot;generation by radiation induces of membrane lipid peroxidation, which leads deterioration of membrane resulting in the change of ion permeability and then hemolysis.