著者

上野 勝次郎 岡田 清三郎

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.82, no.4, pp.532-535, 1962-04-25 (Released:2010-02-19)

参考文献数

10

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Dornow and others synthesized 2-aminonicotinic acid derivatives by the condensation of β-diketone and amidine or imino ethers. Pyridine cyclization by the condensation of β-diketones with non-symmetrical structure and malonamideamidine or ethyl 3-amino-3-ethoxyacrylate was examined and a new derivative of 2-aminonicotinic acid derivatives, which may serve as intermediate for synthesis of pyridoxine, were obtained. The compounds synthesized were ethyl 2-amino-4-ethoxymethyl-6-methylnicotinate, diethyl 2-amino-6-methyl-3, 4-pyridinedicarboxylate, and ethyl 2-amino-4-carbamoyl-6-methylnicotinate, and their structures were determined.