著者

村岡 健一 吉田 哲 長谷川 和正 中西 信夫 福沢 勲 冨田 昭雄 丁 宗鐵

出版者

和漢医薬学会

雑誌

和漢医薬学雑誌 (ISSN:13406302)

巻号頁・発行日

vol.20, no.1, pp.30-37, 2003

参考文献数

19

被引用文献数

2

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In this study, using dogs as experimental models, we observed body temperature rise following administration of "Kakkon-to" preparation, and investigated the average number of macrophages and average rate of phagocytosis of macrophages in blood using the latex microparticles. The body temperature of the Kakkon-to-treated dogs significantly increased 30 minutes after administration (p<0.05). After that, the body temperature was still high until the next administration at 8 hours. When the difference in body temperature before and after administration was compared with that of the control group, a significant in crease was maintained from 1 to 12 hours after administration. The phagocytotic activity of macrophages was also increased. The average number and the average rate of phagocytosis were significantly increased 1 (p<0.05) and 2 (p<0.01) hours after administration, respectively, in comparison with the activity before administration. The significant increases (p<0.01) in both the number and the rate of phagocytosis were continuously found at every measurement point from 2 to 24 hours after administration. In addition, when compared with the control group, the test group showed a significant administration in both the number and the rate of phagocytosis at 3 hours after administration (p<0.01). These results demonstrated that administration of "Kakkon-to" not only increased the body temperature but also enhanced the phagocytic activity of macrophages, the in vivo defensive factors, suggesting that "Kakkon-to" may contribute to the suppression of multiplication of common cold viruses and influenza viruses, which consequently results in improvement of various symptoms during infection with common cold syndrome.