1 0 0 0 選択的P2Yアゴニスト及びアンタゴニストの探索研究
1 0 0 0 OA 有機合成化学から創薬へのアプローチ
- 著者
- 丸岡 博 Maruoka Hiroshi
- 出版者
- 福岡大学研究推進部
- 雑誌
- 福岡大学薬学集報 = Pharmaceutical Bulletin of Fukuoka University (ISSN:13461559)
- 巻号頁・発行日
- vol.7, pp.48-52, 2007-01
- 著者
- 末宗 洋 丸岡 博 佐伯 清太郎 酒井 浄
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- Chemical & pharmaceutical bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.34, no.11, pp.4629-4634, 1986-11-25
This paper describes a conversion of (-)-limonen-10-ol to the key intermediate (1) for 11-deoxyprostaglandin. The 3,4-cis-disubstituted cyclopentanone (2), which was easily obtained from (-)-limonen-10-ol in a stereocontrolled fashion by means of Rh(I)-catalyzed cyclization via the 4-pentenal derivative, could be directly converted to the bicyclo[3.3.0]octenone (3) by treatment with KHSO_4 in boiling benzene. Compound 3 with a double bond at the favorable position was converted to 1 by way of fission of the double bond and subsequent modification of substituents on the five-membered ring.