著者

丹田 均

出版者

社団法人 日本泌尿器科学会

雑誌

日本泌尿器科學會雑誌 (ISSN:00215287)

巻号頁・発行日

vol.62, no.12, pp.925-943, 1971-12-20 (Released:2010-07-23)

参考文献数

87

被引用文献数

2 2

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1) A slight modification of competitive protein binding assay for plasma testosterone of Maeda was studied. 0.25ml of male plasma was sufficient for the assay.2) The change of plasma testosterone level by aging was studied in men. The prepubertal level was 80.92±44.12ng/100ml. That sharply increased between 15 to 19 years of age and reached to the maximum level (670±239.11ng/100ml) in twenties. And then it was gradually decreasing with age. The level in sixties was 334.16±77.54ng/100ml.3) The decreasing process of plasma testosterone level after castration was examined in detail. A 50% deduction was found after 2 to 6 hours and plasma testosterone level reached the prepubertal boy's level after 12 to 24 hours.4) The effect of five days' H. C. G. (5, 000IU) administration on plasma testosterone concentration in normal adult male was studied. The increase in the plasma testosterone level was persistent for a few days even after the cessation of administration.5) After intramuscular injection of 100mg of testosterone propionate the rise in the plasma testosterone level in two normal males rapidly reached a peak in 1 to 5 hours and declined to the base line level in 48 hours. However, in castrated patients, the level slowly reached a peak after 8 to 12 hours and returned to the normal value after 36 to 48 hours.

著者

酒井 茂 熊本 悦明 恒川 琢司 広瀬 崇興 田端 重男 郷路 勉 猪野毛 健男 井川 欣市 田付 二郎 辺見 泉 丹田 均 加藤 修爾 吉尾 弘 生垣 舜二 上野 了 毛利 和弘 出口 浩一

出版者

泌尿器科紀要刊行会

雑誌

泌尿器科紀要 (ISSN:00181994)

巻号頁・発行日

vol.32, no.11, pp.1747-1761, 1986-11

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札幌市における淋菌感染症120例について,症例の疫学的検討を行なうとともに,NFLXの淋菌感染症に対する基礎的,臨床的検討を行った.年齢分布は男女とも20代前半にピークを認めた.感染源は男子では10代はガールフレンド,pick-upなどの素人が70.6%を占め,女子では配偶者が50%,患者自身が特殊浴場従業女子であるものが50%であった.NFLXのN. gonorrhoeaeに対するMIC分布は,0.025 μg/mlにピークをもち,0.0125~3.13 μg/mlに分布した.penicillinase producing Neisseria gonorrhoeae (PPNG)は症例より分離したN. gonorrhoeae 104株中21株(20.2%)であったが,これらのNFLXに対するMICは18株(85.7%)が0.1 μg/ml以下に,3株(14.3%)が1.56~3.13 μg/mlに分布した.NFLX 200 mg経口投与後の血清中濃度は投与2時間後に平均0.72 μg/mlとピークに達し,尿道分泌中濃度は投与1時間後に平均0.5 μg/mlとピークに達した.NFLX 600 mg, 7日間経口投与による淋菌感染症に対する治療成績は,男子尿道炎における有効率が3日間投与で97.4%,7日間投与で93.1%であり,女子子宮頸管炎における有効率は3日間,7日間投与とも100%であり,本剤は淋菌感染症と対する化学療法剤として高い有効性が認められた.淋菌感染症におけるChlamydia trachomatid (C. trachomatis)感染の合併は,男子尿道炎で32.7%,女子子宮頸管炎で20%であり,これらの症例においてはNFLXによる治療後も陰性例よりも分泌物の残存率が高く,引き続きC. trachomatisに対する化学療法が必要と考えられた.NFLX投与による副作用は全く認められず,NFLXは安全に投与できる薬剤と考えられたWe studied the basic and clinical effects of norfloxacin (NFLX) in 120 patients with gonococcal infections (110 men with urethritis and 10 women with cervicitis)--all residents at Sapporo City; and epidemiologically analyzed the sources of their infections. The male patients were between 16 and 67 years old and the female patients were between 20 and 61 years old, with a peak in the early 20s both for sexes. 70.6% of the male patients in their 10s were infected from their girl friends or so-called pick-up friends and 50% of the female patients from their husbands. The other half of the female were workers serving at so-called special massage parlors. The minimum inhibitory concentration (MIC) of NFLX against N. gonorrhoeae distributed was 0.0125 approximately 3.13 micrograms/ml, with a peak at 0.025 micrograms/ml. NFLX inhibited 93.3% of the clinical strains of this species at less than 0.1 microgram/ml and 96.2% at less than 1 microgram/ml, where the inoculation was 10(6) CFU/ml. Twenty one (20.2%) of the 104 N. gonorrhoeae strains were penicillinase-producing one (PPNG). NFLX inhibited 18 of these PPNG (85.7%) at less than 0.1 microgram/ml and the other 3 strains at 1.56 approximately 3.13 micrograms/ml. Oral administration of 200 mg NFLX showed the average peak serum level of 0.72 micrograms/microliter in 2 hours and the average peak level in the urethral secretions of 0.5 micrograms/ml in one hour. These two concentrations of NFLX covered 95.2% of the MIC distribution against N. gonorrhoeae. The clinical efficacy of 600 mg NFLX (peros) was 97.4 and 93.1% for a 3-and 7-day treatment for male urethritis; and 100% for both 3-and 7-day treatment for female cervicitis. Complicated urethritis with C. trachomatis was noticed in 32.7% of the male urethritis and in 20% of the female cervicitis cases. Urethral secretions among about half of these patients were observed even after treatment with NFLX. As a subsequent treatment, another effective chemotherapeutic is required against C. trachomatis. No adverse reactions were detected with NFLX. All the above results demonstrate that NFLX is a highly effective and safe chemotherapeutic agent for treatment of gonorrhoea.

著者

佐藤 嘉一 丹田 均 中嶋 久雄 新田 俊一 赤樫 圭吾 半澤 辰夫 戸邉 武蔵 芳賀 一徳 内田 耕介 本間 一也

出版者

泌尿器科紀要刊行会

雑誌

泌尿器科紀要 = Acta urologica Japonica (ISSN:00181994)

巻号頁・発行日

vol.59, no.5, pp.271-275, 2013-05

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Erectile dysfunction following radical prostatectomy (RP) is still a significant burden as a post-operative morbidity, despite advances in nerve-sparing techniques and penile (erectile function) rehabilitation (PR) programs. We assessed the effects of stimulation with the masturbation device "EGG" on enhancement of erectile response along with administration of phospho diesterase type 5 inhibitor. We also studied the change of self-esteem and motivation for continuation of PR after stimulation with EGG. Eight nonresponders for PDE5-I who underwent retropubic RP were enrolled. Patients' median age was 71.5 years old. No patients received adjuvant therapy for prostate cancer. The patients' erectile response in the penile rehabilitation session (masturbation) with PDE5-I+manual stimulation and PDE5-I+stimulation with EGG were evaluated by erection hardness score (EHS). Changes of self-esteem and motivation for penile rehabilitation were assessed by the self-esteem subscale of the Self-Esteem and Relationship (SEAR) questionnaire and one original question, respectively. PDE5-I + stimulation with EGG significantly enhanced EHS compared to PDE5-I+manual stimulation in the eight patients (p=0.027). Transformed score of self-esteem subscale score of SEAR questionnaire was significantly increased in the PR session with EGG compared to the PR session with manual stimulation (p=0.043). Six patients who showed a better erectile response with EGG retained motivation for continuation of PR. PDE5-I+stimulation with EGG improved the erectile response in post-RP patients. EGG as a masturbation device may have a potential for contribution to successful PR.

著者

小六 幹夫 丹田 均 加藤 修爾 大西 茂樹 中嶋 久雄 南部 明民 新田 俊一 赤樫 圭吾 佐藤 嘉一 半澤 辰夫

出版者

泌尿器科紀要刊行会

雑誌

泌尿器科紀要 (ISSN:00181994)

巻号頁・発行日

vol.48, no.6, pp.333-336, 2002-06

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男性性感染症(STD)患者248例のアンケート調査結果について検討した.感染源は約70%の症例が友人やPick up(いわゆるナンパ)など,金銭の授受を伴わない相手であった.症状出現までに性交渉をもった相手の数は2.8人で,症状出現前のピンポン感染により一般のの人々にSTDが拡大している可能性が考えられた.STDに罹患したことをパートナーに伝えると回答した比率は,59.4%で高い比率では無かった.過去1年間の性交相手は平均5.8人で,若年層ほど高い傾向にあった.コンドーム装着率は12.4%(92/234)ときわめて低かった.Oral sexの頻度は82.0%(192/234)と高率であった.以上から,若年層において,広いsexual networkを形成し,無防備な性交が行われていることが考えられたIn Japan, there has been a rapid increase in recent years in the incidence of sexually transmitted diseases (STD), particularly in teenagers and people in their twenties. To determine the factors causing this increase in STD, we carried out a questionnaire survey on the sexual behavior of Japanese males. The subjects were 248 male patients who were treated at our outpatient clinic. The results of the survey showed that 1) about 70% of the male patients were infected through sexual intercourse with partners who were not paid for such services; 2) the average number of partners in the past year was 5.8, and the average number of partners was highest for the teenage group and decreased with age; 3) only 29 (12.4%) of the 234 males used condoms; and 4) 192 (82.0%) of the 234 males received oral sex. The results of the survey suggest that a large "sexual network" has been formed among young Japanese people and that a large percentage of young Japanese people are engaged in unprotected sex.