著者

加藤 基浩 丹羽 一与 天野 潤 早川 直彦 神山 博 大久保 一三 岡崎 彬

出版者

The Japanese Society for the Study of Xenobiotics

雑誌

薬物動態 (ISSN:09161139)

巻号頁・発行日

vol.8, no.4, pp.481-492, 1993-09-10 (Released:2007-03-29)

参考文献数

17

被引用文献数

1

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We studied the absorption, distribution, excretion and metabolism of 125I-EPOCH after single subcutaneous administration to rats. 1. The levels of immunoreactive rad ioactivity reached the maximum at 8 to 12 hours after dosing and declined monoexponentially with a half-life ranging from 5.77 to 7.47 hours at the doses of 0.5, 1, 5 and 25μg/kg. The MRT of immunoreactive radioactivity after sc dosing ranged from 13.83 to 17.01 hours at any dose levels. F value (AUCsc/AUCiv), which ranged from 0.31 to 0.48, tend to increase in proportion to the administered dose. 2. Most of tissues showed the highest level of total radioactivity at 10 hour after dosing. The level of radioactivity in tissues were lower, than that of serum, except the thyroid gland whose level was the highest. They declined parallel with disappearence of the radioactivity in serum. The level of radioactivity in brain was extremely low. The elimination half-life of radioactivity from the injection site was calculated to be 9h and 1.97% of the dose still remained there at 48 hour. 3. Until 96h after sc administration of 125I-EPOCH at the dose of 1μg/kg, urinary excretions of total, the TCA-precipitable and the immunoreactive radioactivity were 75.89%, 0.35%, 0.05%, respectively. Fecal excretion of total radioactivity was 2.97%, until 96h after dosing. 4. Gel filtration of the plasma showed that the radioactivity of low molecular weight was iodo ion, and that related to radioactivity of high molecular weight appeared mainly as an unchanged 125I-EPOCH.

著者

加藤 基浩 丹羽 一与 天野 潤 早川 直彦 神山 博 大久保 一三 岡崎 彬

出版者

日本薬物動態学会

雑誌

薬物動態 (ISSN:09161139)

巻号頁・発行日

vol.8, no.4, pp.493-503, 1993

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We studied the absorption, distribution and excretion of radioactivity after 4 times multiple subcutaneous administrations of <SUP>125</SUP>I-EPOCH at an interval of 48 hours.<BR> 1. Plasma levels of immunoreactive radioactivity at 10h and 48h following each multiple administration did not change during the experimental period. There were no pronounced differences in pharmacokinetics between first and fourth administration.<BR> 2. The levels of radioactivity in spleen and bone marrow after multiple administration were slightly higher than those after administration of a single dose. Those in other tissues except thyroid gland, were similar to those after administration of a single dose. The remained radioactivity in the injection site at 10h after multiple administration was 33.65%, which was similar to that of single administration.<BR> 3. Until 96h after final administration of <SUP>125</SUP>I-EPOCH, urinary excretions of total. the TCA-precipitable and the immunoreactive radioactivity were 76.43%, 0.97%, 0.49%, respectively. Fecal excretion of total radioactivity was 3.83%, until 96h after final administration.