著者

萬谷 直樹 岡 洋志 佐橋 佳郎 鈴木 理央 綾部 原子 鈴木 まゆみ 神山 博史 長田 潤 木村 容子 伊藤 隆

出版者

一般社団法人 日本東洋医学会

雑誌

日本東洋医学雑誌 (ISSN:02874857)

巻号頁・発行日

vol.66, no.3, pp.197-202, 2015 (Released:2015-11-05)

参考文献数

27

被引用文献数

17 14

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甘草による偽アルドステロン症の頻度については十分にわかっていない。われわれは甘草の1日量と偽アルドステロン症の頻度の関係について,過去の臨床研究を調査した。甘草を1日1g 使用した患者での偽アルドステロン症の頻度は1.0%(平均)であった。1日2g,4g,6g での頻度はそれぞれ1.7%(平均),3.3%,11.1%(平均)であった。過去の文献において,偽アルドステロン症発症頻度の用量依存的な傾向が示唆された。

著者

鈴木 理央 岡 洋志 萬谷 直樹 渡邊 妙子 神山 博史 長崎 直美

出版者

一般社団法人 日本東洋医学会

雑誌

日本東洋医学雑誌 (ISSN:02874857)

巻号頁・発行日

vol.68, no.3, pp.250-254, 2017 (Released:2017-12-26)

参考文献数

18

被引用文献数

3

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顔面痛のある38歳女性。三叉神経痛と診断され,カルバマゼピンで痛みはある程度軽減していたが,漢方治療を希望して来院した。30年前の事故で顔面を強打した既往を手掛かりに,治打撲一方をカルバマゼピンと併用したところ痛みは改善し,高木の圧痛点も軽減もしくは消失し,最終的にカルバマゼピンを廃薬できた。外傷の既往と高木の圧痛点を認める神経痛症例には,同薬を試みる価値があると思われた。

著者

伊藤 慎吾 市川 亮介 本庄 薫平 河合 雅也 田代 良彦 丹羽 浩一郎 石山 隼 杉本 起一 神山 博彦 高橋 玄 柳沼 行宏 小島 豊 田中 真伸 五藤 倫敏 冨木 裕一 坂本 一博

出版者

一般社団法人 日本消化器内視鏡学会 関東支部

雑誌

Progress of Digestive Endoscopy (ISSN:13489844)

巻号頁・発行日

vol.84, no.1, pp.142-143, 2014-06-14 (Released:2014-06-21)

参考文献数

5

被引用文献数

1

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A 68-year-old woman was admitted to the hospital with lower abdominal pain. Abdominal CT revealed a long linear high-density foreign object measuring about 3 cm long, which had penetrated the wall of the sigmoid colon. Emergency endoscopy was performed, because the patient was diagnosed as having possible penetration of the sigmoid colon by a fish bone. The emergency endoscopic examination revealed a fish bone penetrating the sigmoid colon, which was removed with grasping forceps. The removed bone measured 3 cm in length and was believed to belong to a sea bream. The patient was treated conservatively without any complications. For intestinal perforation and penetration caused by a fish bone, such as in our case, endoscopic treatment may be considered as the treatment procedure of first choice.

著者

加藤 基浩 丹羽 一与 天野 潤 早川 直彦 神山 博 大久保 一三 岡崎 彬

出版者

The Japanese Society for the Study of Xenobiotics

雑誌

薬物動態 (ISSN:09161139)

巻号頁・発行日

vol.8, no.4, pp.481-492, 1993-09-10 (Released:2007-03-29)

参考文献数

17

被引用文献数

1

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We studied the absorption, distribution, excretion and metabolism of 125I-EPOCH after single subcutaneous administration to rats. 1. The levels of immunoreactive rad ioactivity reached the maximum at 8 to 12 hours after dosing and declined monoexponentially with a half-life ranging from 5.77 to 7.47 hours at the doses of 0.5, 1, 5 and 25μg/kg. The MRT of immunoreactive radioactivity after sc dosing ranged from 13.83 to 17.01 hours at any dose levels. F value (AUCsc/AUCiv), which ranged from 0.31 to 0.48, tend to increase in proportion to the administered dose. 2. Most of tissues showed the highest level of total radioactivity at 10 hour after dosing. The level of radioactivity in tissues were lower, than that of serum, except the thyroid gland whose level was the highest. They declined parallel with disappearence of the radioactivity in serum. The level of radioactivity in brain was extremely low. The elimination half-life of radioactivity from the injection site was calculated to be 9h and 1.97% of the dose still remained there at 48 hour. 3. Until 96h after sc administration of 125I-EPOCH at the dose of 1μg/kg, urinary excretions of total, the TCA-precipitable and the immunoreactive radioactivity were 75.89%, 0.35%, 0.05%, respectively. Fecal excretion of total radioactivity was 2.97%, until 96h after dosing. 4. Gel filtration of the plasma showed that the radioactivity of low molecular weight was iodo ion, and that related to radioactivity of high molecular weight appeared mainly as an unchanged 125I-EPOCH.

著者

加藤 基浩 丹羽 一与 天野 潤 早川 直彦 神山 博 大久保 一三 岡崎 彬

出版者

日本薬物動態学会

雑誌

薬物動態 (ISSN:09161139)

巻号頁・発行日

vol.8, no.4, pp.493-503, 1993

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We studied the absorption, distribution and excretion of radioactivity after 4 times multiple subcutaneous administrations of <SUP>125</SUP>I-EPOCH at an interval of 48 hours.<BR> 1. Plasma levels of immunoreactive radioactivity at 10h and 48h following each multiple administration did not change during the experimental period. There were no pronounced differences in pharmacokinetics between first and fourth administration.<BR> 2. The levels of radioactivity in spleen and bone marrow after multiple administration were slightly higher than those after administration of a single dose. Those in other tissues except thyroid gland, were similar to those after administration of a single dose. The remained radioactivity in the injection site at 10h after multiple administration was 33.65%, which was similar to that of single administration.<BR> 3. Until 96h after final administration of <SUP>125</SUP>I-EPOCH, urinary excretions of total. the TCA-precipitable and the immunoreactive radioactivity were 76.43%, 0.97%, 0.49%, respectively. Fecal excretion of total radioactivity was 3.83%, until 96h after final administration.