著者

久木田 文夫

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.45, no.1, pp.10-15, 2005 (Released:2005-01-25)

参考文献数

29

被引用文献数

1

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Modern neurophysiology based on ion channels was born a half century ago by Hodgkin and Huxley’s memorial works on ionic currents in squid giant axon. Their finding leads to identification of ion channel proteins containing a voltage-sensor and an aqueous pore. Patch clamping and molecular biological techniques have accelerated to understand how ion channels work. Quite recently we have started to understand ion channel functions on the basis of 3D-structure. This review overviewed a half century progress in understanding of ion channels.