著者

仲田 里瀬 佐藤 三佳子 友永 省三

出版者

日本微量栄養素学会

雑誌

微量栄養素研究 (ISSN:13462334)

巻号頁・発行日

vol.36, pp.66-72, 2019-12-13 (Released:2021-12-13)

参考文献数

26

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Carnosine is a dipeptide composed of β-alanine and l-histidine. Carnosine is an antioxidant and has buffering capacity. In addition, the dipeptide could improve glucose metabolism in animal models. However, the effect of dietary carnosine on various metabolisms has not been clarified in detail. In this study, to explore the effect of carnosine on various metabolisms, we investigated liver and cecal contents in mice given graded amount of carnosine by non-targeted metabolomic analysis. Carnosine didn’t affect body weight while the perirenal fat weight was decreased dose-dependently. In liver and cecal contents, some metabolite levels were significantly influenced. Among them, carnosine levels were increased dose-dependently. These results suggest that dietary carnosine can affect not only carnosine metabolism but also other metabolisms including lipid metabolism. We need further study on the relationships among some metabolites including carnosine and the reduction of fat.