著者

伊藤 孝浩 間瀬 俊明

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.65, no.6, pp.563-574, 2007-06-01 (Released:2010-10-20)

参考文献数

53

被引用文献数

1 1

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Obesity poses a major risk for metabolic diseases like diabetes, hyperlipemia, cardiovascular disease and so on. Endogenous neuropeptide Y (NPY) is mediated by NPY receptors to cause the function which is involved in regulating feeding behavior. Recently, our basic research efforts identified highly potent and orally active NPY receptor antagonists. In this review article, we describe practical syntheses of three drug candidates from process chemistry perspective.