著者

伊藤(新澤) 恭子 村本 和優

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.60, no.5, pp.276-279, 2020 (Released:2020-09-30)

参考文献数

19

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Cytochrome c oxidase in the mitochondrial respiratory chain mostly exists as an independent monomer, or as a monomer associated with the complexes I and III in the supercomplex, although its molecular mechanism has been elucidated based on the crystal structure of its dimeric form. Here, we report detailed comparison of the activity and crystal structure between the monomer and the dimer, and the possibility that the monomer is an activated form, whereas the dimer can be regarded as a physiological standby form in the mitochondrial membrane.