著者

安藤 暢敏 小澤 壮治 中川 基人 佐藤 道夫 池田 佳史 今津 嘉宏 田村 明彦 篠沢 洋太郎 北島 政樹

出版者

日本腹部救急医学会

雑誌

腹部救急診療の進歩 (ISSN:02895021)

巻号頁・発行日

vol.12, no.5, pp.655-659, 1992-10-31 (Released:2011-09-05)

参考文献数

6

被引用文献数

1

著者

豊岡 利正 山崎 壮 谷本 剛 佐藤 恭子 佐藤 道夫 豊田 正武 石橋 無味雄 義平 邦利 内山 充

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.39, no.3, pp.820-822, 1991-03-25 (Released:2008-03-31)

参考文献数

9

被引用文献数

27 42

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To identify chemical contaminant(s) associated with eosinophilia-myalgia syndrome (EMS), case and control lots of tryptophan were analyzed by HPLC with both UV and FL detection. Numerous contaminant peaks appeared on the chromatograms and some of them were identified as 5-hydroxytryptophan, indol aldehyde, indol, etc. from the retention time of authentic compounds. Among these, three peaks were significantly associated with case lots. One corresponds to di-tryptophan aminal of aldehyde (peak E). Ohters are unknown contaminants, UV-5 (FL-7) and UV-28 (FL-36). The structural elucidation and toxicological implication of UV-5 (FL-7) are currently in progress.