著者

廣畑 富雄 増田 義人 堀江 昭夫 倉恒 匡徳

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.64, no.4, pp.323-330_2, 1973-08-31 (Released:2008-10-23)

参考文献数

12

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The carcinogenicity of tar-containing skin drugs, Pityrol, Glyteer, Ichthammol JP. pine tar JP, and Metashal, was investigated by animal experiments and by chemical analysis of carcinogenic aromatic hydrocarbons. The results of animal experiments showed that the proportions of skin papilloma-bearing mice as compared to those at the first appearance of tumor were 64% (Pityrol), 71% (Glyteer), 9% (Ichthammol), 23% (pine tar), and 64% (Metashal). The proportions of skin carcinoma-bearing mice were 36% (Pityrol), 40% (Glyteer), 0% (Ichthammol), 6% (pine tar), and 22% (Metashal). A high proportion (37%) of metastasis in adjacent or remote organs was observed. No tumors developed in the control group that received acetone only.As for chemical analysis, a substantial amount of polycyclic aromatic hydrocarbons and, in particular, of benzo[a]pyrene was identified. The content of benzo[a]-pyrene agreed well with the degree of carcinogenic activity observed by the animal experiment. The average amount of benzo[a]pyrene, from three measurements, were 145 (Pityrol), 129 (Glyteer), none (Ichthammol), 48 (pine tar), and 80μg/10g (Metashal).The carcinogenicity of these drugs in man is difficult to assess at present and further epidemiologic studies appear to be needed to clarify this point.