著者

原口 浩一 遠藤 哲也 阪田 正勝 増田 義人 Mark SIMMONDS

出版者

公益社団法人 日本食品衛生学会

雑誌

食品衛生学雑誌 (ISSN:00156426)

巻号頁・発行日

vol.41, no.4, pp.287-296, 2000-08-25 (Released:2008-01-11)

参考文献数

25

被引用文献数

17 27

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1999年, 全国6都市で販売されていた鯨肉製品61点について, 重金属 (水銀, カドミウム, 鉛) 及び有機塩素系化合物 (PCBs, DDTs, HCHs, HCB, dieldrin) の汚染実態調査を行った. ハクジラの赤身肉では水銀汚染が, ハクジラ及び北太平洋産ミンククジラの脂身にはPCB及び有機塩素系農薬の汚染が顕著にみられた. 鯨肉の多食によってこれらの汚染物質の摂取許容量を超えることも考えられるので, 食品としての安全性を再検討する必要がある.

著者

廣畑 富雄 増田 義人 堀江 昭夫 倉恒 匡徳

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.64, no.4, pp.323-330_2, 1973-08-31 (Released:2008-10-23)

参考文献数

12

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The carcinogenicity of tar-containing skin drugs, Pityrol, Glyteer, Ichthammol JP. pine tar JP, and Metashal, was investigated by animal experiments and by chemical analysis of carcinogenic aromatic hydrocarbons. The results of animal experiments showed that the proportions of skin papilloma-bearing mice as compared to those at the first appearance of tumor were 64% (Pityrol), 71% (Glyteer), 9% (Ichthammol), 23% (pine tar), and 64% (Metashal). The proportions of skin carcinoma-bearing mice were 36% (Pityrol), 40% (Glyteer), 0% (Ichthammol), 6% (pine tar), and 22% (Metashal). A high proportion (37%) of metastasis in adjacent or remote organs was observed. No tumors developed in the control group that received acetone only.As for chemical analysis, a substantial amount of polycyclic aromatic hydrocarbons and, in particular, of benzo[a]pyrene was identified. The content of benzo[a]-pyrene agreed well with the degree of carcinogenic activity observed by the animal experiment. The average amount of benzo[a]pyrene, from three measurements, were 145 (Pityrol), 129 (Glyteer), none (Ichthammol), 48 (pine tar), and 80μg/10g (Metashal).The carcinogenicity of these drugs in man is difficult to assess at present and further epidemiologic studies appear to be needed to clarify this point.