著者

中山 アヤコ 冨田 史子 齋木 このみ 近藤 東臣 砂田 久一 岡本 浩一

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.32, no.5, pp.375-382, 2006-05-10 (Released:2007-11-09)

参考文献数

10

被引用文献数

4 3

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We examined various pharmacokinetic parameters of progesterone (P) after its administration in a vaginal suppository to healthy females and compared these parameters with those after injection of P at different sites, in order to evaluate the effectiveness of the P vaginal suppository. The increase in the blood P concentration after administering it in the vaginal suppository was similar to that for injecting P (25 mg) into the gluteal region. Since the P vaginal suppository is a useful P preparation and can be readily used, it can be the dosage form of first choice in P replacement therapy. In addition, since our basic experiment suggested that there was a circadian rhythm in the blood P concentration, it may be possible to determine the optimum administration time for maintaining the blood P concentration based on this rhythm.