著者

中山 アヤコ 冨田 史子 齋木 このみ 近藤 東臣 砂田 久一 岡本 浩一

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.32, no.5, pp.375-382, 2006-05-10 (Released:2007-11-09)

参考文献数

10

被引用文献数

4 3

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We examined various pharmacokinetic parameters of progesterone (P) after its administration in a vaginal suppository to healthy females and compared these parameters with those after injection of P at different sites, in order to evaluate the effectiveness of the P vaginal suppository. The increase in the blood P concentration after administering it in the vaginal suppository was similar to that for injecting P (25 mg) into the gluteal region. Since the P vaginal suppository is a useful P preparation and can be readily used, it can be the dosage form of first choice in P replacement therapy. In addition, since our basic experiment suggested that there was a circadian rhythm in the blood P concentration, it may be possible to determine the optimum administration time for maintaining the blood P concentration based on this rhythm.

著者

砂田 久一

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.128, no.8, pp.1087-1107, 2008-08-01 (Released:2008-08-01)

参考文献数

49

被引用文献数

3 4

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My main research fields are powder technology, especially solid dosage form, from basic ones to applied ones. Basic ones are physical properties of powder and its packing, compression and computer simulation. Applied ones are preparation and evaluation of granulation, tableting, improvement of solubility of water poor-soluble drug, controlled release tablet and fast disintegrating tablet in the oral cavity. As the chair man of the Standard Formulation Research Council, I have obtained many variable and excellent results. Several results are shown as follow.

著者

福居 篤子 藤井 隆太 砂田 久一

雑誌

薬剤学 = Journal of Pharmaceutical Science and Technology, Japan (ISSN:03727629)

巻号頁・発行日

vol.60, no.1, pp.62-70, 2000-03-20

参考文献数

19

被引用文献数

8

著者

檀上 和美 神谷 明良 池田 栄司 鳥居 佐紀子 砂田 久一 大塚 昭信

出版者

公益社団法人日本薬学会

雑誌

Chemical & pharmaceutical bulletin (ISSN:00092363)

巻号頁・発行日

vol.40, no.9, pp.2505-2509, 1992-09-25

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In the present study, a water/isopropyl alcohol system was selected as the solvent in a hydroxypropylcellulose (HPC) binder solution for the preparation of lactose granules.With a fluidized bed granulation method, the mean granule diameter increased as the adhesion tension (γcosθ) and lactose solubility increased. With an agitating granulation method, the mean granule diameter was independent of the adhesion tension and lactose solubility, but it increased as the viscosity of the binder solution increased.With both granulating methods, greanule hardness increased as the adhesion tension and lactose solubility increased, while the pore volume of the granules decreased as the adhesion tension and lactose solubility increased.The quantitative relationship between the physical properties of the granules and several properties of the solvent solution was investigated by the application of multiple regression analysis.