著者

本間 千裕 加納 太一

出版者

公益社団法人 有機合成化学協会

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.80, no.2, pp.92-102, 2022-02-01 (Released:2022-02-09)

参考文献数

94

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Chiral amine catalysts are widely utilized in various asymmetric reactions. Among them, binaphthyl-based secondary amine catalysts show unique reactivity and unusual stereoselectivity in comparison with frequently used ʟ-proline and its derivatives. In spite of their utility, however, asymmetric reactions employing binaphthyl-based amines are rare because of their synthetic inefficiency. In this context, we have developed chiral secondary amine catalysts based on a phenylcyclopropane scaffold as a novel chiral motif. Newly synthesized amine catalysts function as effective catalysts for several asymmetric reactions. In addition, the phenylcyclopropane-based amino sulfonamide was found to be an effective catalyst for the syn-selective Mannich reaction and conjugate addition with alkynyl Z-ketimines.