4 0 0 0 IR 翻訳 W.イェーガー著:「パイデイア -ギリシア的人間の形成- 」 (2)
- 著者
- 北岡 宏章 中田 裕一 Kitaoka Hiroaki Nakata Yuichi
- 出版者
- 大阪府立工業高等専門学校
- 雑誌
- 大阪府立工業高等専門学校研究紀要 (ISSN:0387365X)
- 巻号頁・発行日
- vol.28, pp.81-89, 1994-06-30
1 0 0 0 OA Thermal Dehydration of Nafagrel Hydrochloride Hydrate at Controlled Water Vapor Partial Pressures
- 著者
- 北岡 宏章 大屋 和美 伯水 英夫
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.43, no.10, pp.1744-1750, 1995-10-15 (Released:2008-03-31)
- 参考文献数
- 11
- 被引用文献数
- 6 6
Nafagrel hydrochloride exists as both a hemihydrate and monohydrate. Conversion from the hemihydrate to the monohydrate is not reversible, and both hydrates can coexist in stable equilibrium between 23% relative humidity (RH) and 64% RH. In order to clarify the dehydration behavior, the kinetics of the thermal dehydration of the hydrates was studied by means of isothermal gravimetry at atmospheric pressure with a controlled water vapor pressure. This revealed that dehydration did not depend on absolute humidity but on RH. The dehydration of the hemihydrate proceeded by two-dimensional gorwth of the nuclei, A2, but the mechanism of monohydrate dehydration changed from A2 to a two-dimensional phase boundary, R2, with an increase in RH. The dehydration of the monohydrate proceeded by R2, resulting in the production of the hemihydrate at 6.5% RH or above. These kinetic analyses showed that the monohydrate dehydrated faster than the hemihydrate.
- 著者
- 北岡 宏章 和田 千佐 諸井 黎明 伯水 英夫
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.43, no.4, pp.649-653, 1995-04-15 (Released:2008-03-31)
- 参考文献数
- 6
- 被引用文献数
- 16 35
Differential scanning calorimetry (DSC) curves of levofloxacin hemihydrate measured under various conditions showed different thermograms. These phenomena were attributed to be the dehydration. Dehydration caused a multiple-phase transition. Dehydration at a higher temperature (above 70°C) gave a sharp endothermic peak on the DSC curve due to the melting of the γ form, and at a lower temperature (below 50°C) gave a sharp endothermic peak due to the melting of the α form.In contrast, the thermal behavior of levofloxacin monohydrate was not affected by dehydration. The difference in the thermal behavior between the hemihydrate and the monohydrate might be attributed to a difference in the interaction between levofloxacin and crystal water. Observations by thermomicroscopy, the changes in powder X-ray diffraction patterns during heating, and single X-ray analysis all supported the above interpretation.