1 0 0 0 OA 肝特異的フェロトーシス制御機構の解明とこれを利用した新規治療法の開発
- 著者
- 山田 直也 唐澤 直義 高橋 将文
- 出版者
- 一般社団法人 日本臓器保存生物医学会
- 雑誌
- Organ Biology (ISSN:13405152)
- 巻号頁・発行日
- vol.29, no.2, pp.128-132, 2022 (Released:2022-08-08)
- 参考文献数
- 21
Ferroptosis is known to be implicated in various liver diseases; however, the liver-specific regulatory mechanism of ferroptosis is not fully understood. We identified 7-dehydrocholesterol reductase (DHCR7) as a novel regulator of ferroptosis in hepatocytes. DHCR7 inhibition suppressed ferroptosis in Huh-7 cells. The DHCR7 inhibition increased the accumulation of intracellular 7-dehydrocholesterol (7-DHC), a substrate for DHCR7, and extrinsic 7-DHC supplementation suppressed ferroptosis. We assessed that oxidation of 7-DHC compensatory prevents cellular membrane lipid peroxidation related to ferroptosis. DHCR7 inhibitor also suppressed ferroptosis in murine primary hepatocytes and hepatic ischemia-reperfusion injury in mice. These findings suggest that targeting DHCR7 is a potential therapeutic strategy for ferroptosis-related liver disease.
1 0 0 0 OA 転写因子SREBP-1の動脈硬化とリポタンパク質代謝に及ぼす影響の解明
- 著者
- 唐澤 直義
- 巻号頁・発行日
- 2012
筑波大学博士 (医学) 学位論文・平成24年3月23日授与 (甲第6224号)