著者
岩井 聡美
出版者
一般社団法人 日本臓器保存生物医学会
雑誌
Organ Biology (ISSN:13405152)
巻号頁・発行日
vol.19, no.1, pp.109-112, 2012-07-10 (Released:2014-11-26)
参考文献数
11
著者
佐野 元昭
出版者
一般社団法人 日本臓器保存生物医学会
雑誌
Organ Biology (ISSN:13405152)
巻号頁・発行日
vol.23, no.2, pp.117-120, 2016 (Released:2016-08-31)
参考文献数
6

Early application of therapeutic hypothermia, rapid achievement of target cooling temperature were key factors for improving survival and neurological outcomes. In the present situation, targeted Temperature Management (TTM) is applied to only a minority of post-cardiac arrest patients. We have been looking forward to seeing widely applicable therapeutic approaches. We previously demonstrated that both inhalation of 2% hydrogen gas and TTM (33°C), starting at the beginning of cardiopulmonary resuscitation and given for 2 hours after return of spontaneous circulation (ROSC), yielded comparable improvement in survival and neurological deficit after ROSC in a rat model of cardiac arrest. However, in a clinical setting, hypothermia is applied after ROSC. We have confirmed that the benefit of hydrogen inhalation is similar when begun after ROSC.We would like to emphases a salutary effect of hydrogen gas inhalation on the neurological outcome after cardiopulmonary resuscitation independently of TTM in rats. Inhalation hydrogen gas therapy, either alone or in the combined with TTM, could represent a promising strategy to improve brain resuscitation for post cardiac arrest patients in the near future.
著者
木須 伊織
出版者
一般社団法人 日本臓器保存生物医学会
雑誌
Organ Biology (ISSN:13405152)
巻号頁・発行日
vol.25, no.1, pp.35-40, 2018 (Released:2018-03-14)
参考文献数
13

Uterus transplantation (UTx) has become an alternative to gestational surrogacy and adoption for women with uterine factor infertility. Brännström et al. achieved the first human delivery after UTx in 2014 and to date a total of 8 babies have been born after UTx from living donors. This outcome attracted much attention worldwide and many countries have recently prepared for UTx. However, this procedure has many medical, ethical and social issues that require discussion prior to clinical application. Moreover, UTx is still in the experimental stage overseas and the safety and efficacy remain unclear despite several clinical applications. Despite the many issues to be resolved, this new organ transplantation technology will provide new hope for women with uterine factor infertility and further development of the technology is important for future reproductive and transplant medicine.
著者
山田 陽城
出版者
一般社団法人 日本臓器保存生物医学会
雑誌
Organ Biology (ISSN:13405152)
巻号頁・発行日
vol.25, no.1, pp.56-70, 2018 (Released:2018-03-14)
参考文献数
46

Nature is a very important resource for not only new drug discovery but also application of traditional medicines. Kampo (Japanese traditional) medicines have been used as the traditional formula in which multi-active ingredients may attack multiple target sites to recover complicated symptoms caused by disturbance of the body systems such as immune, neural and endocrine systems. Therefore, their multilateral actions are suitable to treat multifactorial diseases. Kampo medicines are using for the treatment depending on the patient’s clinical situation, either separately or to complement modern western medicine in Japan. Present review describes the concept and characterization of Kampo medicines, and introduces our pharmacological studies of Kampo medicines to clarify their action mechanism and active ingredients. The results may contribute for more evidence-based clinical applications of Kampo medicines.
著者
若杉 安希乃
出版者
一般社団法人 日本臓器保存生物医学会
雑誌
Organ Biology (ISSN:13405152)
巻号頁・発行日
vol.23, no.1, pp.46-52, 2016 (Released:2016-06-22)
参考文献数
8
被引用文献数
1

Of 627 physicians targeted by Japan Kampo Medicines Manufacturers Association (JKMA) as part of “Factual Investigation on Prescription of Kampo Medicines 2011,” 89% prescribed Kampo medicines on a daily basis. The department that ranked the highest in prescribing Kampo medicines was Obstetrics and Gynecology (97%), followed by Internal Medicine (96%), Surgery (95%), Neuropsychiatry (92%), and Orthopedics (90%). Thus, the majority of the departments ranked high (above 90%). However, the results of a questionnaire survey administered by Nikkei TRENDY to 1000 doctors asking, “Will you take Kampo medicines when you fall sick?” 31% of them take Kampo medicine positively, 39% - not basically, and17%- not at all. That is, majority of the doctors answered, “No, I do not take Kampo medicines.” The reasons were “poor evidence” and “ambiguous diagnoses.” Although Kampo is a traditional Japanese medicine, it is not completely appreciated owing to negative impressions such as “poor evidence”, “unscientific”, and so on. On the other hand, manufacturers often promote health foods or cosmetics, taking advantage of their positive impression such as “less side effects”, “mild effects”, and so on. In this review, the outline the details of Kampo medicine and highlight the accumulated evidence concerning Kampo in an attempt to clearing the misunderstanding about Kampo. It is required that doctors and pharmacists promote high-quality clinical practice and research by adopting a viewpoint on Kampo medicine to uphold this traditional medicine.
著者
本間 真人 平野 俊彦 湯沢 賢治 大河内 信弘 剣持 敬
出版者
一般社団法人 日本臓器保存生物医学会
雑誌
Organ Biology (ISSN:13405152)
巻号頁・発行日
vol.24, no.1, pp.76-80, 2017 (Released:2017-03-31)
参考文献数
7

Questionnaire survey concerning practical use of generic immunosuppressive agents and the European Society for Organ Transplantation (ESOT) guideline was conducted in 130 clinical institutions including transplant hospitals where the members of The Japan Society for Organ Preservation and Biology were working. Forty five institutions answered the questionnaire survey (the recovery rate: 34.6%). Use of generic immunosuppressive agents in the institutions has been different among the agents; tacrolimus (6.7%), cyclosporin (8.9%) and mycophenorate mofetil (8.9%) and corticosteroid injection (51.1%). The results indicated that use of generic immunosuppressive agents, especially in the agents that require therapeutic drug monitoring (TDM) for dose adjustment, have not been spread in Japan. The most of the institutions (greater than 62%) agreed with the ESOT guideline for generic substitution of immunosuppressive agents. It is considered that the Japanese guideline is also required to prepare according to ESOT guideline, though the use of generic products have not been popular yet Japan.
著者
中村 知夫
出版者
一般社団法人 日本臓器保存生物医学会
雑誌
Organ Biology (ISSN:13405152)
巻号頁・発行日
vol.27, no.1, pp.21-30, 2019 (Released:2020-03-01)
参考文献数
20

急性期治療の後に, 医療ケアーや, 医療機器を必要とする子どもが増加している. これらの子どもたちは, 初期そして専門医療やその他の保育, 教育, 福祉, 社会サービスを利用することは容易ではない. そのために, これらの子どもたちは今まで病院や施設のみに存在すると考えられていた. しかし, 今まで高齢者が主に利用していた在宅医療を子どもたちが利用できるようになってきている. 近い将来, これらの医療的ケア児も, 地域包括ケアシステムや地域共生社会の恩恵を受けることができることが期待されている.
著者
大見 和宏
出版者
一般社団法人 日本臓器保存生物医学会
雑誌
Organ Biology (ISSN:13405152)
巻号頁・発行日
vol.20, no.1, pp.36-44, 2013-01-30 (Released:2014-11-26)
参考文献数
33

The blood brain barrier has important roles for physiological and pathological state in the brain. The molecules involved in barrier function have been identified. Now we can analyze these molecules by genomics and proteomics methods. The blood brain barrier is also called neurovascular unit which is composed of brain capillary endothelial cells, astrocytes, pericytes, neurons and microglia. They closely interacted with each other for the development and maintenance of blood brain barrier functions. In this review I will summarize some basic concepts and recent new findings about blood brain barrier:structure and function, neurological diseases, proteomics method, in vitro experimental system, and enzyme replacement therapy for lysosomal storage diseases/mucopolysaccharidosis.
著者
剣持 敬 伊藤 泰平 星長 清隆
出版者
一般社団法人 日本臓器保存生物医学会
雑誌
Organ Biology (ISSN:13405152)
巻号頁・発行日
vol.20, no.2, pp.159-164, 2013-07-10 (Released:2014-11-26)
参考文献数
3

The organ procurement team must evaluate whether the organs such as liver, small intestine, pancreas, kidney can be procured or not by the donor conditions, past history, present illness, blood chemistry and ultrasonography. Before donor operation, multiorgan procurement teams should discuss about the order of organ procurement, crossclamp, blood drainage, perfusion technique and the division of the vessels. Donation of the abdominal organs from brain-dead donor is performed with the procedure of multiorgan donation technique. In the abdominal organs, small intestine is first extracted followed by the extraction of the liver and pancreas separately or en bloc. When the liver is solitary procured, en bloc procurement of pancreas and kidneys is popular in Japan. In the back table, the pancreas was isolated from the kidney grafts followed by the separation of both kidney grafts. Both kidneys are divided by the division of the aorta, the vena cava and the connective tissues. The kidney grafts are perfused with UW solution before packing on ice.
著者
半田 宏 伊藤 拓水 安藤 秀樹
出版者
一般社団法人 日本臓器保存生物医学会
雑誌
Organ Biology (ISSN:13405152)
巻号頁・発行日
vol.21, no.2, pp.134-140, 2014-07-10 (Released:2014-11-10)
参考文献数
9

Half a century ago, the sedative thalidomide caused one of the worst notorious drug disasters in history, with more than 10,000 babies born with deformities. The drug is now used in the treatment of multiple myeloma. Recently new thalidomide derivatives called immunomodulatory drugs (IMiDs) have been developed. Among them, lenalidomide and pomalidomide have excellent anti-cancer activity. However, the use of them is limited due to its potent teratogenic activity. The mechanism by which IMiDs including thalidomide induce birth defects and therapeutic effects was a long-standing question. Using an affinity beads technology we originally developed, we have identified cereblon(CRBN)as a primary target of IMiDs. CRBN forms an E3 ubiquitin ligase complex. IMiDs alter the activity and induce various biological effects such as teratogenicity, anti-cancer and immunomodulation.Understanding IMiDs and CRBN may lead to uncover new therapeutic pathways for overcoming refractory cancer diseases.
著者
竹内 朋代 野口 雅之 川上 康 大河内 信弘
出版者
一般社団法人 日本臓器保存生物医学会
雑誌
Organ Biology (ISSN:13405152)
巻号頁・発行日
vol.23, no.1, pp.21-28, 2016 (Released:2016-06-22)
参考文献数
9

Biobank is the facility for preserving and providing biospecimens such as human cells, tissues and blood with their clinical data. Every year the establishment biobank has increased all over the world. The human biospecimens are rarely provided for researchers who want to use them for life-science research in Japan; the preservation is done well, though. Recently the ethical guidelines for life-science research using of human biospecimens have been amended. Through this revision, researchers can be easy to use these human biospecimens than before. It is expected this will provide the chances to progress life-science research. The next step of banking the human biospecimens is to examine the quality of the samples and to prepare the standard operating procedure. It is also extremely expected that biobank will be the basis for research toward the highly advanced medical technology.
著者
杉山 健太郎 磯貝 和也 坂爪 重明 外山 聡 佐藤 博 齋藤 和英 中川 由紀 田﨑 正行 高橋 公太 平野 俊彦
出版者
一般社団法人 日本臓器保存生物医学会
雑誌
Organ Biology (ISSN:13405152)
巻号頁・発行日
vol.18, no.1, pp.47-51, 2011-06-10 (Released:2014-11-26)
参考文献数
10

Renal transplant recipients are administered immunosuppressive therapy to prevent acute rejection. In particular, new immunosuppressive agents have helped to improve the allograft survival rate and reduce the rate of rejection in renal transplant recipients. The optimal dose of calcineurin inhibitors is determined by therapeutic drug monitoring. However, the pharmacological efficacy of cyclosporine and tacrolimus should be estimated using both pharmacokinetics and pharmacodynamic parameters. We therefore employed the lymphocyte immunosuppressant sensitivity test(LIST) with the 3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium bromide(MTT)assay procedure to evaluate renal transplant recipients. The LIST with the MTT assay procedure can predict the pharmacological efficacy of immunosuppressive drugs using peripheral blood mononuclear cellsMoreover, renal transplant recipients must be correctly treated with immunosuppressive agents and another medicines. Therefore, the pharmacist must provide instructions for all medications to maintain adherence in renal transplantation. Therefore, transplantation therapy must be based on the pharmaceutical care given by pharmacists.
著者
和田 恭一
出版者
一般社団法人 日本臓器保存生物医学会
雑誌
Organ Biology (ISSN:13405152)
巻号頁・発行日
vol.24, no.1, pp.13-19, 2017 (Released:2017-03-31)
参考文献数
11

One year-mortality of end-stage heart failure is about 50%, which is comparable to those of terminal cancers. Recently, new curriculum for specialists of clinical pharmacology for chemotherapy of cancer has been released. Likewise, we need to create specialized clinical pharmacists for the management of end-stage heart failure.These pharmacists will be called as “Transplant Pharmacist”. In this article, we will outline our effort as the special team for the management of the patients waiting for heart transplant and the post-heart transplant patients. Transplant pharmacists will play a pivotal role in this team activity. Prevention of thromboembolism in the patients with left ventricular assist device (LVAD) needs close therapeutic drug monitoring (TDM) and rapid feedback of data on warfarin. In addition to these actions, successful management of warfarin requires that the transplant pharmacists effectively counsel and educate these patients with LVAD. TDM of antibiotic drugs is also essential for treatment of infection with LVAD. On the other hand, immunosuppressant like cyclosporine, tacrolimus, mycophenolate mofetil and evelolimus have critical influence on graft rejection as well as susceptibility to infection. Transplant pharmacists should evaluate effective the plasma concentration of those drugs through Parmacokinetics/Pharmacodynamics (PK/PD). Immunosuppressant adherence is also a critical issue to heart transplant recipient. Therefore, constant counseling and educating to these patients from transplant pharmacists are necessary.Transplant pharmacists skilled at PK/PD and TDM of cardiovascular, antibiotic and immunosuppressive drugs would be key talents in highly-sophisticated medicine in the future.
著者
竹内 裕紀 岩本 整 中村 有紀 河地 茂行 島津 元秀 畝崎 榮 平野 俊彦
出版者
一般社団法人 日本臓器保存生物医学会
雑誌
Organ Biology (ISSN:13405152)
巻号頁・発行日
vol.22, no.1, pp.7-22, 2015 (Released:2015-09-10)
参考文献数
59

Corticosteroids or steroids are useful drug in clinical renal transplantation because of multiple effects in immunosuppression. There are not a few renal transplant recipients who need steroid therapy, although various new immunosuppressive drugs have developed. However, steroid dosage should be kept as low as possible and preferably withdrawn, because adverse effects of steroids are the most problematical in immunosuppressive drugs. The individual difference of efficacy and adverse effects of steroids depends on pharmacodynamics factor. We have been tried to resolve the dual nature of steroid therapy by steroid sensitivities test using peripheral blood mononuclear cell(PBMC). We clarified significant relationship in steroid sensitivity and clinical outcome, relative immunosuppressive efficacy of steroid, availability of methylprednisolone as immunosuppressive drug, utility for selecting patients who can sustain steroid withdrawal, and pharmacodynamic interaction of calcineurin inhibitors and steroids. We describe here not only results of pharmacodynamic research of steroid sensitivity test, but also comprehensive issues, i. e., history of steroid therapy in renal transplantation, action mechanism of steroid and factor of individual difference of steroid sensitivity, pharmacokinetics of steroid, suppression of hypothalamic-pituitary-adrenal system and immune system, adverse effects of steroid, and practice toward optimal steroid therapy for individual renal recipients.
著者
矢野 育子
出版者
一般社団法人 日本臓器保存生物医学会
雑誌
Organ Biology (ISSN:13405152)
巻号頁・発行日
vol.26, no.2, pp.131-137, 2019 (Released:2019-09-26)
参考文献数
14

A physiologically based pharmacokinetic model adapted to the clinical data was constructed in order to evaluate the contribution of liver regeneration as well as hepatic and intestine CYP3A5 genotypes on tacrolimus pharmacokinetics in adult patients after living-donor liver transplantation. As a result, the oral clearance of tacrolimus was affected by the CYP3A5 genotypes in both the liver and intestine to the same extent. Population pharmacokinetic and pharmacodynamic analysis of mycophenolate was performed in 49 patients undergoing hematopoietic stem cell transplantation. Simulations based on the final parameters show that the dosage adjustment based on plasma concentrations of mycophenolate is required especially for patients with renal dysfunction and/or diarrhea. In conclusion, pharmacometrics is a useful methodology for individualized and optimized therapy of immunosuppressants.
著者
石川 洋一
出版者
一般社団法人 日本臓器保存生物医学会
雑誌
Organ Biology (ISSN:13405152)
巻号頁・発行日
vol.25, no.1, pp.51-55, 2018 (Released:2018-03-14)
参考文献数
6

Children needs the dosage forms suitable for pediatric use. A surface body area and weight change rapidly by the age. Therefore the dosage flexibility for pediatric formulation is needed. Moreover, oral medication has to be good taste. Development of age-appropriate medicine is important, because it usually influences children’s treatment adherence. Recently, improved technology of the orally disintegrating tablet (ODT) in Japan and the active development of mini-tablets formulation in foreign countries is attracting attention. The pediatric medicine manufacturing laboratory started by our center facilitates support the promotion of development of pediatric formulation.
著者
岩本 整 杉本 昌弘 沖原 正章 赤司 勲 木原 優 今野 理
出版者
一般社団法人 日本臓器保存生物医学会
雑誌
Organ Biology (ISSN:13405152)
巻号頁・発行日
vol.27, no.2, pp.125-131, 2020 (Released:2020-08-19)
参考文献数
38

The early and accurate diagnosis of rejection after renal transplantation is required for the well-being of recipients. To develop minimally invasive diagnosis the wide variety of novel biomarkers has been evaluated in biofluids such as blood and urea, using metabolomics that performs simultaneous identification and quantification of hundreds of metabolites. Here, we reviewed the recent researches to explore the biomarkers applicable for the diagnosis of rejection after renal transplantation.
著者
林 昌洋
出版者
一般社団法人 日本臓器保存生物医学会
雑誌
Organ Biology (ISSN:13405152)
巻号頁・発行日
vol.18, no.3, pp.279-286, 2011-12-10 (Released:2014-11-26)
参考文献数
17

While careful consideration to avoid a second scourge like thalidomide is required, disadvantages for mothers and fetuses by restraint of necessary drug prescription because of too much concern about the effects on fetuses must be avoided. Information sources to evaluate teratogenicity of drugs themselves include epidemiological investigations, case reports, and animal reproduction studies and are considered more reliable in this order. And breast milk is the best source of nutrition and it also serves as a source of substances providing immunity for a newborn infant. However, there are times when nursing mothers may have to take some kind of medication, so it is necessary to evaluate the effect of drugs that are transferred to infants through breast milk, and to select medications with minimal adverse effects.