2 0 0 0 OA アプタマー創薬と構造生物学
- 著者
- 坂本 泰一
- 出版者
- 日本結晶学会
- 雑誌
- 日本結晶学会誌 (ISSN:03694585)
- 巻号頁・発行日
- vol.60, no.2-3, pp.129-134, 2018-05-31 (Released:2018-06-02)
- 参考文献数
- 25
Aptamers are nucleic acids that bind to a target molecule with high affinity and specificity, which are selected from systematic evolution of ligands by exponential enrichment (SELEX). Because of their high affinity and specificity, aptamers are strong candidates of next generation molecular targeted agents. However, for the development of aptamer therapeutics, chemical modification of aptamers is required to improve their nuclease resistance. For the efficient modification, structural information could be important. In this review, I describe structural biology of aptamers.
1 0 0 0 OA NMRによる立体構造解析におけるresidual dipolar couplingの利用
- 著者
- 坂本 泰一 染谷 龍彦
- 出版者
- 社団法人 日本分光学会
- 雑誌
- 分光研究 (ISSN:00387002)
- 巻号頁・発行日
- vol.49, no.5, pp.257-258, 2000-10-15 (Released:2010-06-28)
- 参考文献数
- 5