著者

田中 聡 山本 一徹 権藤 学司 渡辺 剛史 堀田 和子 田中 貴大 田中 雅彦

出版者

日本脊髄外科学会

雑誌

脊髄外科 (ISSN:09146024)

巻号頁・発行日

vol.35, no.3, pp.312-315, 2021 (Released:2021-12-28)

参考文献数

13

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Calcification of ligamentum flavum (CLF) is a degenerative spinal disease in which calcium crystals deposit in the ligamentum flavum. The CLF may cause spinal cord compression, and the patient may need decompressive surgery. However, CLF can spontaneously regress with some medications as well as no treatment. Here, the authors reported a case in which small CLF remaining after cervical decompression surgery markedly enlarged during the follow-up period and spontaneously regressed after pregabalin administration. Therefore, pregabalin might be involved in the spontaneous regression of CLF.  A 66-year-old female complaining of right upper limb pain and numbness was diagnosed with CLF at C5/6 and C6/7 by computed tomography (CT) and magnetic resonance imaging (MRI). The symptoms improved after removal of the CLF at C5/6 with C5 laminectomy and C4, C6 laminoplasty. Postoperative CT showed small residual CLF at C6/7. Six years after surgery, she suffered pain and numbness in her right arm. Her cervical MRI showed a marked increase of CLF at C6/7. The pain disappeared after the administration of pregabalin. Six months later, a marked reduction of CLF was observed on MRI.  It has been reported that the administration of cimetidine or etidronate resulted in the regression of CLF. Cimetidine affects calcium metabolism via parathyroid hormone (PTH), and etidronate has an inhibitory effect on calcification. It was reported that the serum PTH was markedly reduced in a uremic patient after the administration of pregabalin. The efficacy of pregabalin was also reported for a case with refractory paroxysmal kinesigenic choreoathetosis whose parathyroid glands were removed. It is presumed that pregabalin was involved in calcification regression via PTH metabolism in this case.

著者

渡辺 剛史 権藤 学司 田中 雅彦 山本 一徹 堀田 和子 玉井 洋太郎 田中 聡

出版者

日本脊髄外科学会

雑誌

脊髄外科 (ISSN:09146024)

巻号頁・発行日

vol.33, no.2, pp.170-174, 2019 (Released:2019-09-10)

参考文献数

12

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The purpose of this article is to analyze the characteristics of spinal magnetic resonance images (MRI) in multiple myeloma patients. Two hundred and eighteen patients were diagnosed with multiple myelomas at the Shonan Kamakura General Hospital from January 2009 to April 2018. Spinal MRIs were evaluated in 66 cases. Initial symptoms, spinal MRI findings, and blood sample test findings at the time of diagnosis were investigated. There were 37 males and 29 females analyzed. Mean age at the time of diagnosis was 70.1 years (42 to 87 years). Main initial symptoms were low back pain (n=23), back pain (n=15), neck pain (n=1), lower limb weakness (n=6), lower limb pain/paresthesia (n=4), cranial nerve palsy (n=2), respiratory symptoms (n=6), renal failure (n=4), anemia (n=3) and asymptomatic (n=6). Spinal MRI revealed vertebral fracture (n=42), intravertebral tumor (n=35), epidural tumor (n=9), diffuse spotty signal (n=13), and diffuse low signal (n=4). There were only five cases where no abnormality was observed beyond the vertebral body fracture. Dural sac compression was observed in 16 cases, of which 12 cases were co-localized with the tumor and 4 cases were by a fractured bony fragment. The results of the blood sampling were confirmed in 65 patients. Anemia, decreased albumin/globulin ratio, hyperproteinemia, hypercalcemia, and increased alkaline phosphatase were observed in 57, 44, 29, 13, and 12 patients, respectively. Only 9 cases showed normal blood test results. The most common symptom of multiple myeloma was lower back pain. As such, half of the patients had visited an orthopedic or spinal surgery clinic. Spinal MRI findings were classified as intervertebral focal lesion, epidural mass, diffuse spotty signal, or diffuse low signal. The presence of an abnormal finding was observed in 92% of patients by spinal MRI and in 86% by blood sampling. Spinal MRI and blood sampling examination should be considered in cases of vertebral fracture in order to prevent the misdiagnosis of multiple myeloma as an osteoporotic vertebral fracture.

著者

帆足 英一 帆足 英一 庄司 順一 堀田 和子 帆足 暁子 池田 宏

出版者

日本保育学会大会準備委員会

雑誌

日本保育学会大会研究論文集

巻号頁・発行日

no.47, 1994