著者
犬山 征夫 浅岡 一之 中島 康夫 甲能 直幸 小津 雷助 増野 精二 堀内 正敏
出版者
耳鼻咽喉科臨床学会
雑誌
耳鼻咽喉科臨床 (ISSN:00326313)
巻号頁・発行日
vol.72, no.12, pp.1613-1620, 1979-12-01 (Released:2011-11-04)
参考文献数
15
被引用文献数
1

We gave OK-432, a preparation made from a low virulent strain of streptococcus hemolyticus, to 68 patients with head and neck cancer by intramuscular injection and 2 patients were treated with local application. Anatomical site of the tumor in 70 cases was as follows; nose and paranasal sinus 22, nasopharynx 17, base of oral cavity and tongue 14, mesopharynx 8, larynx 6 and miscellaneous 3. We administered OK-432 mainly as an adjuvant immunotherapy after radical surgery or radiotherapy. The daily dose of OK-432 was 0.2KE, then the dose was gradually augmented and the maintenance dose was 3-5KE. The longest duration of OK-432 administration was 3 years and 6 months. We evaluated OK-432 from the point of view of the immunological parameters and the recurrence rate. Complement level (CH50) and tuberculin reactivity were measured as possible indices of the humoral and cell-mediated immune status. “The six stage classification after CH50 and tuberculin reaction” as suggested by Nishioka was employed and an analysis carried out.The results obtained were as follows:1. OK-432 had no tumor-reducing effects in advanced or recurrent cases.2. Immunological findings suggested that OK-432 had prophylactic effects against recurrence and metastasis.3. The recurrence rate of OK-432-treated group was almost the same as that in the control group, however, the recurrence rate of OK-432 and FT-207 treated groups was 26%, this rate being considerably lower than that in the control group. We concluded that adjuvant chemo-immunotherapy was more effective than adjuvant immunotherapy alone for prevention of recurrence and metastasis.