著者

大山 廣太郎 石井 秀弥 鈴木 団

出版者

公益社団法人 日本生物工学会

雑誌

生物工学会誌 (ISSN:09193758)

巻号頁・発行日

vol.100, no.8, pp.433-436, 2022-08-25 (Released:2022-08-25)

参考文献数

16

著者

下澤 東吾 小比類巻 生 大山 廣太郎 照井 貴子 福田 紀男

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.59, no.1, pp.009-013, 2019 (Released:2019-01-26)

参考文献数

20

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In vivo nano-imaging is today’s key technology for understanding cellular and molecular functions on a real-time basis in living organisms. In mammals, including humans, the heart sends blood to the lungs and to the rest of the body each time it beats, only under the in vivo conditions. However, to date, sarcomeric contractions, which are the basis of myocardial dynamic behavior, have not been directly observed in vivo due to technical hurdles. In this article, we describe our newly developed in vivo cardiac nano-imaging microscope for mice, and discuss recent, novel findings obtained under true physiologic conditions by using this cutting-edge technology.