著者

太田 博道

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.41, no.11, pp.1018-1030, 1983-11-01 (Released:2010-01-22)

参考文献数

119

被引用文献数

3 4

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Recently, organic syntheses are directed toward very complex compounds and hence the development of highly selective reactions is required. Thus, it becomes increasingly important to utilize enzymatic reactions as key steps in organic synthesis. This article reviews the recent topics in microbial and enzymatic oxidations of organic compounds and their application to the synthesis of physiologically active compounds. The application of the biological systems are classified into types of reactions including, a) oxidation of saturated C-H bonds, b) oxidation of unsaturated bonds, c) oxidation of alcohols, d) oxidation of sulfides. Emphasis is placed to the chemo-, regio-, and stereo-selectivities of the reactions. Reductive reactions containing C-C bond formations are also described briefly.

著者

太田 博道

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.46, no.8, pp.726-741, 1988-08-01 (Released:2010-01-22)

参考文献数

199

被引用文献数

15 13

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Microbial and enzymatic transformation of synthetic substrates is attracting much attention as a useful method in synthetic organic chemistry. In this article, recent developements in this field are reviewed, dividing into three major sections which include oxidation, reduction and hydrolysis reactions. Methods for increasing the selectivity of some reactions are also described. Emphasis has been placed to the formation of optically active compounds, because enzymes are able to catalyze asymmetric reactions under mild conditions.