著者

二木 力夫 柿本 守夫 宇佐美 正義 鈴木 繁生 高垣 善男

出版者

公益社団法人 日本化学療法学会

雑誌

CHEMOTHERAPY (ISSN:00093165)

巻号頁・発行日

vol.24, no.4, pp.703-721, 1976-04-20 (Released:2011-03-08)

参考文献数

10

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Potential nephrotoxicity of ceftezole (CTZ) and cefazolin (CEZ) was studied in rabbits by intravenous injections.A single injection of 125, 250, 500 and 1000 mg/kg of CTZ or CEZ caused a dose-related renal injury. This was confirmed by the results of tests of clearance (PAH), PSP excretion, BUN and protein and sugar in urine, and also by macro-and micro-scopic examination of kidneys. CTZ or CEZ injection of 500 and 1000 mg/kg resulted in alteration of renal functions and caused a necrosis of proximal tubules, while 125 and 250 mg/kg administrations did not cause a renal injury.In rabbits injected CTZ or CEZ, twice daily for 7 consecutive days at a dose of 64 and 125 mg/kg, no abnormalities were observed to be attributable to the drug treatment in both renal functions and kidney structure.CTZ or CEZ injections at doses of 50 and 100 mg/kg/day for 21 consecutive days would have been not caused a renal injury, while 200 mg/kg dose caused a slight alteration in renal functions, and CTZ injection at doses of 200 mg/kg/day caused slight necrosis to the least extent in proximal tubules.CTZ seemed to have much less nephrotoxic potential than CEZ.